Synthetic cells represent a rapidly advancing frontier in engineering biology, offering new ways to understand living systems and developing innovative solutions across health, environmental management, agriculture, and manufacturing. Constructed from biomolecular components and designed to perform life-like functions, synthetic cells have the potential to enable more predictable, controllable, and adaptable biological technologies with wide-ranging societal and economic benefits.
Supporting Responsible Innovation of Synthetic Cells: Biosafety, Biosecurity, and Environmental Considerations examines how this emerging field can advance while addressing biosafety, biosecurity, and environmental considerations. The report finds that many risks associated with synthetic cells are similar to those posed by existing chemical and microbial systems but may arise in new ways due to novel combinations of features, boundary-blurring system architectures, and emerging applications, creating uncertainty for risk-benefit evaluation and oversight.
To support responsible innovation, the report outlines a path forward grounded in adaptive, evidence-based, and proportionate governance. Key recommendations include establishing a coordinated national biotechnology governance strategy, strengthening the empirical data and research infrastructure for risk assessment, modernizing biosafety and biosecurity oversight, and promoting transparency, public engagement, and international collaboration.
By aligning scientific advancement with adaptive and coordinated governance, this report provides a framework for ensuring that synthetic cell research develops in ways that are safe, secure, and responsive to societal needs, helping realize the promise of this emerging technology while managing uncertainty and risk.
Topics: Biology and Life Sciences » Biotechnology | Policy for Science and Technology » Research and Data
Global demand for animal-derived foods such as meat, eggs, and milk is increasing, even as arable land and water to support animal production are declining worldwide. Among the approaches to meet global demand in a resource-constrained future is the genetic improvement of livestock to increase the efficiency and sustainability of animal agriculture. Food-animal breeders are beginning to leverage advances in the fields of genomics and biotechnology to make targeted changes in DNA, called heritable genetic modifications (HGMs), that can be passed onto subsequent generations, thereby significantly accelerating the process of genetic improvement in populations of food animals.
At the request of Congress, Heritable Genetic Modification in Food Animals examines the biological basis of potential health risks relevant to the regulation of HGMs in food animals. This report considers whether hazards could arise during the development of HGM food animals, the methods available to detect hazards, and the likelihood that they could result in harm. Heritable Genetic Modification in Food Animals recommends conducting additional research to fill gaps in understanding of how both HGM techniques and conventional breeding methods influence animal welfare and the quality of animal foods, establishing a study group to gauge public attitudes toward animal biotechnology in agriculture, and developing best practices for public engagement regarding such technologies.
Topics: Biology and Life Sciences » Genetics | Agriculture » Animal Health and Nutrition
Artificial intelligence (AI) applications in the life sciences have the potential to enable advances in biological discovery and design at a faster pace and efficiency than is possible with classical experimental approaches alone. At the same time, AI-enabled biological tools developed for beneficial applications could potentially be misused for harmful purposes. Although the creation of biological weapons is not a new concept or risk, the potential for AI-enabled biological tools to affect this risk has raised concerns during the past decade.
This report, as requested by the Department of Defense, assesses how AI-enabled biological tools could uniquely impact biosecurity risk, and how advancements in such tools could also be used to mitigate these risks. The Age of AI in the Life Sciences reviews the capabilities of AI-enabled biological tools and can be used in conjunction with the 2018 National Academies report, Biodefense in the Age of Synthetic Biology, which sets out a framework for identifying the different risk factors associated with synthetic biology capabilities.
Topics: Conflict and Security Issues » Biosecurity | Biology and Life Sciences » Biotechnology | Biology and Life Sciences » Policy, Reviews and Evaluations
Chronic wasting disease (CWD) is a fatal, infectious prion disease affecting the central nervous system of some species of Cervidae-animals such as deer, elk, and moose. Recognized as a disease in the 1980s but suspected to have been present in the United States for decades longer, CWD affects both captive and free-ranging cervids and has been reported in 35 states and five Canadian provinces of North America as of August 1, 2024. The potential ramifications of the increasing spread of CWD are serious, and include negative impacts on ecosystems, and large economic costs for agencies with management responsibilities related to cervids and for industries that depend on cervids or cervid products. Cultural and food security impacts for communities with traditions tied to cervid hunting are also impacted.
In 2020, Congress passed America's Conservation Enhancement (ACE) Act (P.L. 116-188), directing the U.S. Fish and Wildlife Service to lead a task force for addressing CWD in the United States drawing on a study commissioned from the National Academies. This report will assist the task force in prioritizing research and developing future CWD management strategies. It describes the state of knowledge regarding how CWD is transmitted among cervids, the current distribution of disease outbreaks, and the effectiveness of current diagnostic, prevention, and control methods available to limit the spread of the disease.
Topics: Biology and Life Sciences » Animals, Plants and Other Organisms | Environment and Environmental Studies » Ecology and Ecosystems
Our planet is facing many complex environmental challenges, including the loss of biodiversity and rapidly changing climate conditions, driven by intensifying human-nature interactions worldwide. Dramatic advances in the biological sciences over recent years are made possible by new tools to study life at many scales, from identifying mutations in a single gene to monitoring changes in plants, animals, and microbes over an entire continent. These tools have the potential to usher in a new era of continental-scale biology (CSB) in which researchers can combine data from various realms across organizational, spatial, and temporal scales, addressing questions on biological processes and patterns that cannot be answered by observations at either small or large scales alone.
This report, prepared at the request of the National Science Foundation, sets out a vision for the development of CSB and identifies the research areas that could most benefit from multi-scale approaches. Advancing the use of CSB to address a wide range of biological and societal challenges will require the development of integrated conceptual frameworks and theories to guide research, deployment of emerging technologies, and development of a skilled workforce to synthesize the vast amounts of data from various sources.
Topics: Biology and Life Sciences » Biodiversity | Environment and Environmental Studies » Climate Change | Environment and Environmental Studies » Policy, Reviews and Evaluations
Concerted efforts to deepen understanding of RNA modifications and their role in living systems hold the potential to advance human health, improve crop yields, and address other pressing societal challenges. RNA, which carries the information encoded by DNA to the places where it is needed, is amazingly diverse and dynamic. RNA is processed and modified through natural biological pathways, giving rise to hundreds, in some cases thousands, of distinct RNA molecules for each gene, thereby diversifying genetic information. RNA modifications are known to be pivotal players in nearly all biological processes, and their dysregulation has been implicated in a wide range of human diseases and disorders. Yet, our knowledge of RNA modifications remains incomplete, hindered by current technological limitations. Existing methods cannot discover all RNA modifications, let alone comprehensively sequence them on every RNA molecule. Nonetheless, what is known about RNA modifications has already been leveraged in the development of vaccines that helped saved millions of lives worldwide during the COVID-19 pandemic. RNA modifications also have applications beyond health, for example, enhancing agricultural productivity.
Charting a Future for Sequencing RNA and Its Modifications: A New Era for Biology and Medicine calls for a focused, large-scale effort to accelerate technological innovation to harness the full potential of RNA modifications to address pressing societal challenges in health, agriculture, and beyond. This report assesses the scientific and technological breakthroughs, workforce, and infrastructure needs to sequence RNA and its modifications, and ultimately understand the roles RNA modifications play in biological processes and disease. It proposes a roadmap of innovation that will make it possible for any RNA from any biological system to be sequenced end-to-end with all of its modifications - a capability that could lead to more personalized and targeted treatments and instigate transformative changes across various sectors beyond health and medicine.
Topics: Biology and Life Sciences » Genetics | Health and Medicine » Genetics | Health and Medicine » Health Sciences
This concise and beautifully illustrated booklet expresses the Academy's view on the teaching of creationism alongside evolution in the science classroom—"The tenets of 'creation science' are not supported by scientific evidence....Creationism has no place in a science curriculum at any level...." This is an essential tool for educators, school administrators, students, and parents—anyone with an interest in the quality of science education. This booklet is a reissue that updates the 1984 edition.
Topics: Biology and Life Sciences » Biology
As part of its core mission, the U.S. Environmental Protection Agency (EPA) is tasked with assessing the hazards and risks to human health from exposure to pollutants. While some pollutants are well studied, there are little or no data on the potential health effects for many thousands of chemicals that can make their way into the environment, such as PFAS. EPA still relies on laboratory mammalian studies as the foundation of most human health risk assessments, which are limited by high costs, long timelines, and other concerns. New approach methods (NAMs) in toxicology, for example new in vivo and in vitro strategies and computational systems biology, offer opportunities to inform timely decision-making when no data are available from laboratory mammalian toxicity tests or epidemiological studies. NAMs may also help inform efforts to protect susceptible and vulnerable populations by characterizing subtle health perturbations, better encompassing genetic diversity, and accounting for nonchemical stressors.
While the promise and need for NAMs is clear, many barriers to their use remain. This report aims to bridge the gap between the potential of NAMs and their practical application in human health risk assessment. Building Confidence in New Evidence Streams for Human Health Risk Assessment draws lessons learned from laboratory mammalian toxicity tests to help inform approaches for building scientific confidence in NAMs and for incorporating such data into risk assessment and decision-making. Overall, the report recommendations aim to ensure a seamless handoff from the evaluation of NAM-based testing strategies in the laboratory to the incorporation of NAM data into modern, systematic-review-based risk assessments.
Topics: Biology and Life Sciences » Laboratory Animal Research
One strategy cells use for regulation is modifying proteins, DNA, and RNA to control their structure, function, and stability. For years, research has focused on the reversible modifications to proteins and DNA. However, RNA can also be highly modified, and more than 170 types of modification to RNA have been identified so far. Current methods for mapping and sequencing RNA and its modifications - also known as the epitranscriptome - are limited, partly because available sequencing technologies can detect only a small number of them. This limits the understanding of different molecular processes and leaves a gap in knowledge related to human diseases and disorders.
To address these limitations and develop a roadmap for the sequencing of RNA with the epitranscriptome, the National Academies of Sciences, Engineering, and Medicine convened an ad hoc committee to provide a consensus report. A workshop held on March 14-15, 2023 was one part of an information-gathering effort by the committee and is summarized in this proceedings.
Topics: Biology and Life Sciences » Genetics | Biology and Life Sciences » Policy, Reviews and Evaluations
In 2023, the National Academies held a series of facilitated workshops to gather information on progress to date on projects funded by the National Science Foundation (NSF) Understanding the Rules of Life (URoL) program. A fundamental goal of the URoL program is to identify the causal, predictive relationships that drive how life functions—a concept articulated as the "rules of life." Principal investigators of the URoL program shared findings from their research and how those findings might contribute to identifying rules of life that are generalizable across fields and scales. Participants also discussed how they have incorporated multidisciplinary, systems-level approaches into their work. This booklet highlights the program's focus areas and reach, major scientific breakthroughs, and lessons for research and education across scientific disciplines. This booklet is intended for policy and lay audiences interested in learning more about the goals and opportunities of NSF's URoL program.
Topics: Biology and Life Sciences » Policy, Reviews and Evaluations
Artificial intelligence (AI), facial recognition, and other advanced computational and statistical techniques are accelerating advancements in the life sciences and many other fields. However, these technologies and the scientific developments they enable also hold the potential for unintended harm and malicious exploitation. To examine these issues and to discuss practices for anticipating and preventing the misuse of advanced data analytics and biological data in a global context, the National Academies of Sciences, Engineering, and Medicine convened two virtual workshops on November 15, 2022, and February 9, 2023. The workshops engaged scientists from the United States, South Asia, and Southeast Asia through a series of presentations and scenario-based exercises to explore emerging applications and areas of research, their potential benefits, and the ethical issues and security risks that arise when AI applications are used in conjunction with biological data. This publication highlights the presentations and discussions of the workshops.
Topics: Biology and Life Sciences » Biotechnology | Biology and Life Sciences » Policy, Reviews and Evaluations
Nonhuman primates represent a small fraction of animals used in biomedical research, but they remain important research models due to their similarities to humans with respect to genetic makeup, anatomy, physiology, and behavior. Limitations in the availability of nonhuman primates have been exacerbated by the COVID-19 pandemic and recent restrictions on their exportation and transportation, impacting National Institutes of Health (NIH)-funded research necessary for both public health and national security. Additionally, there is continued interest in understanding whether and how nonanimal models can be used to answer scientific questions for which nonhuman primates are currently used.
At the direction of the U.S. Congress, NIH asked the National Academies of Sciences, Engineering, and Medicine to convene an expert committee to conduct a landscape analysis of current and future use of nonhuman primates in NIH-supported biomedical research, as well as opportunities for new approach methodologies to complement or reduce reliance on nonhuman primate models. This report provides the committee findings and conclusions.
Topics: Biology and Life Sciences » Laboratory Animal Research | Health and Medicine » Health Sciences | Health and Medicine » Policy, Reviews and Evaluations
At the request of the U.S. Government, the National Academies of Sciences, Engineering, and Medicine established a standing committee to identify future biotechnology needs for national security. The standing committee identifies and explores in detail new and emerging research and development of biotechnologies of interest to national security. Communication and Information Transmission Using Biotechnology: Abridged Version is the public version of the committee's classified consensus study that describes current research on DNA, protein, and small molecule-based approaches for transmitting information and the nascent field of molecular communication.
Topics: Biology and Life Sciences » Biotechnology | Biology and Life Sciences » Policy, Reviews and Evaluations
A growing body of evidence has sounded the alarm that the biodiversity that supports and sustains life on Earth is at risk. Habitat destruction, resource exploitation, and climate change are among the many stressors that have put 1 million species under threat of extinction and sharply reduced the populations of many plant and animal species. While researchers and global leaders ramp up efforts to address this existential threat, the significance of species loss and the value of preserving biodiversity is not widely recognized by policy makers or the public. This booklet, produced by an international committee of experts, provides a publicly accessible overview of the many dimensions of biodiversity and why it's vital to the health of all life on the planet. The booklet also examines the causes of biodiversity loss and presents actions that can be taken from the individual to the global level to stop this decline.
Topics: Biology and Life Sciences » Biodiversity | Biology and Life Sciences » Policy, Reviews and Evaluations
Biological collections are a critical part of the nation's science and innovation infrastructure and a fundamental resource for understanding the natural world. Biological collections underpin basic science discoveries as well as deepen our understanding of many challenges such as global change, biodiversity loss, sustainable food production, ecosystem conservation, and improving human health and security. They are important resources for education, both in formal training for the science and technology workforce, and in informal learning through schools, citizen science programs, and adult learning. However, the sustainability of biological collections is under threat. Without enhanced strategic leadership and investments in their infrastructure and growth many biological collections could be lost.
Biological Collections: Ensuring Critical Research and Education for the 21st Century recommends approaches for biological collections to develop long-term financial sustainability, advance digitization, recruit and support a diverse workforce, and upgrade and maintain a robust physical infrastructure in order to continue serving science and society. The aim of the report is to stimulate a national discussion regarding the goals and strategies needed to ensure that U.S. biological collections not only thrive but continue to grow throughout the 21st century and beyond.
Topics: Biology and Life Sciences » Biology | Biology and Life Sciences » Policy, Reviews and Evaluations
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing.
From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Topics: Health and Medicine » Genetics | Biology and Life Sciences » Genetics
Research and innovation in the life sciences is driving rapid growth in agriculture, biomedical science, information science and computing, energy, and other sectors of the U.S. economy. This economic activity, conceptually referred to as the bioeconomy, presents many opportunities to create jobs, improve the quality of life, and continue to drive economic growth. While the United States has been a leader in advancements in the biological sciences, other countries are also actively investing in and expanding their capabilities in this area. Maintaining competitiveness in the bioeconomy is key to maintaining the economic health and security of the United States and other nations.
Safeguarding the Bioeconomy evaluates preexisting and potential approaches for assessing the value of the bioeconomy and identifies intangible assets not sufficiently captured or that are missing from U.S. assessments. This study considers strategies for safeguarding and sustaining the economic activity driven by research and innovation in the life sciences. It also presents ideas for horizon scanning mechanisms to identify new technologies, markets, and data sources that have the potential to drive future development of the bioeconomy.
Topics: Biology and Life Sciences » Biotechnology | Biology and Life Sciences » Policy, Reviews and Evaluations
The U.S. Fish and Wildlife Service commissioned the National Academies of Sciences, Engineering, and Medicine to develop a request for applications, "Research to determine the taxonomy of wild canid populations in regions of the United States where recent evidence suggests the potential presence of red wolves (Canis rufus)," and to conduct an independent evaluation of the submitted applications. This letter report describes the work of the committee and transmits the final evaluation of applications to carry out research.
Topics: Biology and Life Sciences » Animals, Plants and Other Organisms | Biology and Life Sciences » Policy, Reviews and Evaluations
Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused.
Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.
Topics: Biology and Life Sciences » Biotechnology | Conflict and Security Issues » Military and Defense Studies
People's desire to understand the environments in which they live is a natural one. People spend most of their time in spaces and structures designed, built, and managed by humans, and it is estimated that people in developed countries now spend 90 percent of their lives indoors. As people move from homes to workplaces, traveling in cars and on transit systems, microorganisms are continually with and around them. The human-associated microbes that are shed, along with the human behaviors that affect their transport and removal, make significant contributions to the diversity of the indoor microbiome.
The characteristics of "healthy" indoor environments cannot yet be defined, nor do microbial, clinical, and building researchers yet understand how to modify features of indoor environments—such as building ventilation systems and the chemistry of building materials—in ways that would have predictable impacts on microbial communities to promote health and prevent disease. The factors that affect the environments within buildings, the ways in which building characteristics influence the composition and function of indoor microbial communities, and the ways in which these microbial communities relate to human health and well-being are extraordinarily complex and can be explored only as a dynamic, interconnected ecosystem by engaging the fields of microbial biology and ecology, chemistry, building science, and human physiology.
This report reviews what is known about the intersection of these disciplines, and how new tools may facilitate advances in understanding the ecosystem of built environments, indoor microbiomes, and effects on human health and well-being. It offers a research agenda to generate the information needed so that stakeholders with an interest in understanding the impacts of built environments will be able to make more informed decisions.
Topics: Biology and Life Sciences » Biology | Engineering and Technology » Construction: Design, Research, Planning
Biodiversity—the genetic variety of life—is an exuberant product of the evolutionary past, a vast human-supportive resource (aesthetic, intellectual, and material) of the present, and a rich legacy to cherish and preserve for the future. Two urgent challenges, and opportunities, for 21st-century science are to gain deeper insights into the evolutionary processes that foster biotic diversity, and to translate that understanding into workable solutions for the regional and global crises that biodiversity currently faces. A grasp of evolutionary principles and processes is important in other societal arenas as well, such as education, medicine, sociology, and other applied fields including agriculture, pharmacology, and biotechnology. The ramifications of evolutionary thought also extend into learned realms traditionally reserved for philosophy and religion.
The central goal of the In the Light of Evolution (ILE) series is to promote the evolutionary sciences through state-of-the-art colloquia—in the series of Arthur M. Sackler colloquia sponsored by the National Academy of Sciences—and their published proceedings. Each installment explores evolutionary perspectives on a particular biological topic that is scientifically intriguing but also has special relevance to contemporary societal issues or challenges. This tenth and final edition of the In the Light of Evolution series focuses on recent developments in phylogeographic research and their relevance to past accomplishments and future research directions.
Topics: Biology and Life Sciences » Evolution
Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation.
Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.
Topics: Biology and Life Sciences » Biotechnology | Agriculture » Crop and Plant Production | Biology and Life Sciences » Genetics
Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration.
Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
Topics: Biology and Life Sciences » Biotechnology | Biology and Life Sciences » Genetics
In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease—several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors.
Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.
Topics: Health and Medicine » Cancer | Health and Medicine » Women's Health | Biology and Life Sciences » Genetics
The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology.
Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.
Topics: Math, Chemistry, and Physics » Chemistry | Biology and Life Sciences » Biotechnology | Industry and Labor » Industrial and Manufacturing Technologies
By 2050 the world's population is projected to grow by one-third, reaching between 9 and 10 billion. With globalization and expected growth in global affluence, a substantial increase in per capita meat, dairy, and fish consumption is also anticipated. The demand for calories from animal products will nearly double, highlighting the critical importance of the world's animal agriculture system. Meeting the nutritional needs of this population and its demand for animal products will require a significant investment of resources as well as policy changes that are supportive of agricultural production. Ensuring sustainable agricultural growth will be essential to addressing this global challenge to food security.
Critical Role of Animal Science Research in Food Security and Sustainability identifies areas of research and development, technology, and resource needs for research in the field of animal agriculture, both nationally and internationally. This report assesses the global demand for products of animal origin in 2050 within the framework of ensuring global food security; evaluates how climate change and natural resource constraints may impact the ability to meet future global demand for animal products in sustainable production systems; and identifies factors that may impact the ability of the United States to meet demand for animal products, including the need for trained human capital, product safety and quality, and effective communication and adoption of new knowledge, information, and technologies.
The agricultural sector worldwide faces numerous daunting challenges that will require innovations, new technologies, and new ways of approaching agriculture if the food, feed, and fiber needs of the global population are to be met. The recommendations of Critical Role of Animal Science Research in Food Security and Sustainability will inform a new roadmap for animal science research to meet the challenges of sustainable animal production in the 21st century.
Topics: Biology and Life Sciences » Laboratory Animal Research | Biology and Life Sciences » Policy, Reviews and Evaluations
This report is the Thai translation of Guide for the Care and Use of Laboratory Animals: Eighth Edition.
A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use:
The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
Topics: Biology and Life Sciences » Laboratory Animal Research | Agriculture » Animal Health and Nutrition | Biology and Life Sciences » Policy, Reviews and Evaluations
Humans possess certain unique mental traits. Self-reflection, as well as ethic and aesthetic values, is among them, constituting an essential part of what we call the human condition. The human mental machinery led our species to have a self-awareness but, at the same time, a sense of justice, willing to punish unfair actions even if the consequences of such outrages harm our own interests. Also, we appreciate searching for novelties, listening to music, viewing beautiful pictures, or living in well-designed houses. But why is this so? What is the meaning of our tendency, among other particularities, to defend and share values, to evaluate the rectitude of our actions and the beauty of our surroundings? What brain mechanisms correlate with the human capacity to maintain inner speech, or to carry out judgments of value? To what extent are they different from other primates' equivalent behaviors?
In the Light of Evolution Volume VII aims to survey what has been learned about the human "mental machinery." This book is a collection of colloquium papers from the Arthur M. Sackler Colloquium "The Human Mental Machinery," which was sponsored by the National Academy of Sciences on January 11-12, 2013. The colloquium brought together leading scientists who have worked on brain and mental traits. Their 16 contributions focus the objective of better understanding human brain processes, their evolution, and their eventual shared mechanisms with other animals. The articles are grouped into three primary sections: current study of the mind-brain relationships; the primate evolutionary continuity; and the human difference: from ethics to aesthetics. This book offers fresh perspectives coming from interdisciplinary approaches that open new research fields and constitute the state of the art in some important aspects of the mind-brain relationships.
Topics: Biology and Life Sciences » Biology | Biology and Life Sciences » Evolution
The U.S. veterinary medical profession contributes to society in diverse ways, from developing drugs and protecting the food supply to treating companion animals and investigating animal diseases in the wild. In a study of the issues related to the veterinary medical workforce, including demographics, workforce supply, trends affecting job availability, and capacity of the educational system to fill future demands, a National Research Council committee found that the profession faces important challenges in maintaining the economic sustainability of veterinary practice and education, building its scholarly foundations, and evolving veterinary service to meet changing societal needs.
Many concerns about the profession came into focus following the outbreak of West Nile fever in 1999, and the subsequent outbreaks of SARS, monkeypox, bovine spongiform encephalopathy, highly pathogenic avian influenza, H1N1 influenza, and a variety of food safety and environmental issues heightened public concerns. They also raised further questions about the directions of veterinary medicine and the capacity of public health service the profession provides both in the United States and abroad.
To address some of the problems facing the veterinary profession, greater public and private support for education and research in veterinary medicine is needed. The public, policymakers, and even medical professionals are frequently unaware of how veterinary medicine fundamentally supports both animal and human health and well-being. This report seeks to broaden the public's understanding and attempts to anticipate some of the needs and measures that are essential for the profession to fulfill given its changing roles in the 21st century.
Topics: Agriculture » Animal Health and Nutrition | Biology and Life Sciences » Animals, Plants and Other Organisms | Biology and Life Sciences » Policy, Reviews and Evaluations
The central goal of the In the Light of Evolution (ILE) series is to promote the evolutionary sciences through state-of-the-art colloquia—in the series of Arthur M. Sackler colloquia sponsored by the National Academy of Sciences—and their published proceedings. Each installment explores evolutionary perspectives on a particular biological topic that is scientifically intriguing but also has special relevance to contemporary societal issues or challenges.
This book is the outgrowth of the Arthur M. Sackler Colloquium "Brain and Behavior," which was sponsored by the National Academy of Sciences on January 20-21, 2012, at the Academy's Arnold and Mabel Beckman Center in Irvine, CA. It is the sixth in a series of Colloquia under the general title "In the Light of Evolution." Specifically, In Light of Evolution: Brain and Behavior focuses on the field of evolutionary neuroscience that now includes a vast array of different approaches, data types, and species.
This volume is also available for purchase with the In the Light of Evolution six-volume set.
Topics: Biology and Life Sciences » Biology | Biology and Life Sciences » Evolution
The committee evaluated submissions received in response to a request for proposals (RFP) for Biomolecular Simulation Time on Anton, a supercomputer specially designed and built by D.E. Shaw Research (DESRES) that allows for dramatically increased molecular dynamics simulations compared to other currently available resources. During the past 2 years, DESRES has made available to the non-commercial research community node-hours on an Anton system housed at the Pittsburgh Supercomputing Center (PSC), based on the advice of previous National Research Council committees convened in the falls of 2010 and 2011.
The success of the program has left DESRES to make the Anton machine housed at the PSC available for an additional 3.7 million node-hours during the 9 months following October 2012. DESRES has asked the National Research Council (NRC) to once again facilitate the allocation of time to the non-commercial research community. To undertake this task, the NRC convened a committee of experts to evaluate the proposals submitted in response to the aforementioned RFP. The committee members were selected for their expertise in molecular dynamics simulations, as well as their experience in the subject areas represented in the 52 proposals that were considered by the committee. They comprised a cross-section of the biomolecular dynamics field in academia, industry, and government, including an array of both senior and junior investigators.
The goal of the third RFP for Biomolecular Simulation Time on Anton has been to continue to facilitate breakthrough research in the study of biomolecular systems by providing a massively parallel system specially designed for molecular dynamics simulations. These special capabilities allow multi-microsecond to millisecond simulation timescales, which previously had been unobtainable. The program seeks to continue to support research that addresses important and high-impact questions demonstrating a clear need for Anton's special capabilities.Report of the Committee on Proposal Evaluation for Allocation of Supercomputing Time for the Study of Molecular Dynamics: Third Round is a summary of the proposals, research, and criteria set forth in the RFP for Biomolecular Simulation Time on Anton.
Topics: Biology and Life Sciences » Biotechnology | Computers and Information Technology » Computers
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised?
Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Topics: Biology and Life Sciences » Genetics
Biodiversity—the genetic variety of life—is an exuberant product of the evolutionary past, a vast human-supportive resource (aesthetic, intellectual, and material) of the present, and a rich legacy to cherish and preserve for the future. Two urgent challenges, and opportunities, for 21st-century science are to gain deeper insights into the evolutionary processes that foster biotic diversity, and to translate that understanding into workable solutions for the regional and global crises that biodiversity currently faces. A grasp of evolutionary principles and processes is important in other societal arenas as well, such as education, medicine, sociology, and other applied fields including agriculture, pharmacology, and biotechnology. The ramifications of evolutionary thought also extend into learned realms traditionally reserved for philosophy and religion.
The central goal of the In the Light of Evolution (ILE) series is to promote the evolutionary sciences through state-of-the-art colloquia—in the series of Arthur M. Sackler colloquia sponsored by the National Academy of Sciences—and their published proceedings. Each installment explores evolutionary perspectives on a particular biological topic that is scientifically intriguing but also has special relevance to contemporary societal issues or challenges. This book is the outgrowth of the Arthur M. Sackler Colloquium "Cooperation and Conflict," which was sponsored by the National Academy of Sciences on January 7-8, 2011, at the Academy's Arnold and Mabel Beckman Center in Irvine, California. It is the fifth in a series of colloquia under the general title "In the Light of Evolution." The current volume explores recent developments in the study of cooperation and conflict, ranging from the level of the gene to societies and symbioses.
Humans can be vicious, but paradoxically we are also among nature's great cooperators. Even our great conflicts-wars-are extremely cooperative endeavors on each side. Some of this cooperation is best understood culturally, but we are also products of evolution, with bodies, brains, and behaviors molded by natural selection. How cooperation evolves has been one of the big questions in evolutionary biology, and how it pays or does not pay is a great intellectual puzzle. The puzzle of cooperation was the dominant theme of research in the early years of Darwin's research, whereas recent work has emphasized its importance and ubiquity. Far from being a rare trait shown by social insects and a few others, cooperation is both widespread taxonomically and essential to life. The depth of research on cooperation and conflict has increased greatly, most notably in the direction of small organisms.
Although most of In the Light of Evolution V: Cooperation and Conflict is about the new topics that are being treated as part of social evolution, such as genes, microbes, and medicine, the old fundamental subjects still matter and remain the object of vigorous research. The first four chapters revisit some of these standard arenas, including social insects, cooperatively breeding birds, mutualisms, and how to model social evolution.
Topics: Biology and Life Sciences » Biodiversity | Biology and Life Sciences » Biology | Biology and Life Sciences » Evolution
In 2003, the Boston University Medical Center (BUMC) was awarded a $128 million grant from the National Institutes of Health (NIH) to build one of two national maximum-containment laboratory facilities for pathogen research. The National Emerging Infectious Diseases Laboratories (NEIDL) are meant to support the National Institute of Allergy and Infectious Diseases' biodefense research agenda, conducting research to develop new approaches to treating, preventing, and diagnosing a variety of bacterial and viral diseases. The facility includes a biosafety level 4 (BSL-4) containment laboratory housed in a 192,000 square foot building. Although the NEIDL BSL-4 laboratory accounts for only 13 percent of the building's total space, it has been the source of virtually all of the community concern surrounding this project. The location of the facility on Albany Street in Boston's South End, which is an environmental justice community, has been controversial, and there have been numerous public meetings over the plans for the facility as well as three legal actions challenging the project.
Continuing Assistance to the National Institutes of Health on Preparation of Additional Risk Assessments for the Boston University NEIDL, Phase 3, the fifth in a series of reports about the proposed facility, provides further technical input on the scope and design of any additional studies that may be needed to assess the risks associated with the siting and operation of the NEIDL. This report presents comments and questions on a "90 percent", or penultimate, draft of the revised risk assessment. According to the report, the "90 percent" draft of the risk assessment is a substantial improvement over past documents reviewed. Additionally, the report makes recommendations to improve the version that is ultimately prepared for public comment.
Topics: Biology and Life Sciences » Biology | Biology and Life Sciences » Animals, Plants and Other Organisms
During the last decade, national and international scientific organizations have become increasingly engaged in considering how to respond to the biosecurity implications of developments in the life sciences and in assessing trends in science and technology (S&T) relevant to biological and chemical weapons nonproliferation. The latest example is an international workshop, Trends in Science and Technology Relevant to the Biological Weapons Convention, held October 31 - November 3, 2010 at the Institute of Biophysics of the Chinese Academy of Sciences in Beijing.
Life Sciences and Related Fields summarizes the workshop, plenary, and breakout discussion sessions held during this convention. Given the immense diversity of current research and development, the report is only able to provide an overview of the areas of science and technology the committee believes are potentially relevant to the future of the Biological and Toxic Weapons Convention (BWC), although there is an effort to identify areas that seemed particularly ripe for further exploration and analysis. The report offers findings and conclusions organized around three fundamental and frequently cited trends in S&T that affect the scope and operation of the convention:
The report does not make recommendations about policy options to respond to the implications of the identified trends. The choice of such responses rests with the 164 States Parties to the Convention, who must take into account multiple factors beyond the project's focus on the state of the science.
Topics: Biology and Life Sciences » Biotechnology | Conflict and Security Issues » Weapons and Technology | Conflict and Security Issues » Biosecurity
The Committee on Proposal Evaluation for Allocation of Supercomputing Time for the Study of Molecular Dynamics evaluated submissions received in response to a Request for Proposals (RFP) for Biomolecular Simulation Time on Anton, a supercomputer specially designed and built by D.E. Shaw Research (DESRES) that allows for dramatically increased molecular dynamics simulations compared to other currently available resources. Over the past year (October 1, 2010—September 30, 2011), DESRES has made available to the non-commercial research community 3,000,000 node-hours on an Anton system housed at the Pittsburgh Supercomputing Center (PSC), based on the advice of a previous National Research Council committee convened in the fall of 2010.
The goal of the second RFP for Biomolecular Simulation Time on Anton has been to continue to facilitate breakthrough research in the study of biomolecular systems by providing a massively parallel system specially designed for molecular dynamics simulations. These special capabilities allow multi-microsecond to millisecond simulation timescales, which previously had been unobtainable. The program seeks to continue to support research that addresses important and high impact questions demonstrating a clear need for Anton's special capabilities. The Anton RFP described the three criteria against which the committee was asked to evaluate proposals: Scientific Merit, Justification for Requested Time Allocation, and Investigator Qualifications and Past Accomplishments.
Topics: Computers and Information Technology » Computers | Biology and Life Sciences » Biotechnology
The Reference Manual on Scientific Evidence, Third Edition, assists judges in managing cases involving complex scientific and technical evidence by describing the basic tenets of key scientific fields from which legal evidence is typically derived and by providing examples of cases in which that evidence has been used.
First published in 1994 by the Federal Judicial Center, the Reference Manual on Scientific Evidence has been relied upon in the legal and academic communities and is often cited by various courts and others. Judges faced with disputes over the admissibility of scientific and technical evidence refer to the manual to help them better understand and evaluate the relevance, reliability and usefulness of the evidence being proffered. The manual is not intended to tell judges what is good science and what is not. Instead, it serves to help judges identify issues on which experts are likely to differ and to guide the inquiry of the court in seeking an informed resolution of the conflict.
The core of the manual consists of a series of chapters (reference guides) on various scientific topics, each authored by an expert in that field. The topics have been chosen by an oversight committee because of their complexity and frequency in litigation. Each chapter is intended to provide a general overview of the topic in lay terms, identifying issues that will be useful to judges and others in the legal profession. They are written for a non-technical audience and are not intended as exhaustive presentations of the topic. Rather, the chapters seek to provide judges with the basic information in an area of science, to allow them to have an informed conversation with the experts and attorneys.
Topics: Policy for Science and Technology » Policy for Science and Technology | Biology and Life Sciences » Genetics | Behavioral and Social Sciences » Law and Justice
We are living in an age when scientific knowledge is of the utmost concern to all mankind. The proper use of scientific knowledge can result in unparalleled benefits to mankind and a misuse can lead to unimaginable disasters.
Heredity and Development: Second Edition describes the progress of genetics as it took place and in so doing evaluates some of the problems facing scientists who are working on unknown phenomena. The principal purpose is to show how ideas in these two fields were formulated and studied. The intellectual history of the two has been quite different. Therefore, the report provides a foundation of the data and concepts in the field of genetics and an understanding of the manner in which science develops.
Emphasizing the manner in which hypotheses and observations lead to the conceptual schemes that allow us to think in an orderly and satisfying way about the problems involved, Heredity and Development explores the subsciences of genetics and embryology detailing a range of topics from Darwin's Theory of Pangenesis, and Mendelism to DNA structure and function, and differentiation. Used chiefly in college biology and genetics courses, the text is essential to decision makers, including those without a scientific background.
Topics: Biology and Life Sciences » Genetics
Less than a month after the September 11, 2001 attacks, letters containing spores of anthrax bacteria (Bacillus anthracis, or B. anthracis) were sent through the U.S. mail. Between October 4 and November 20, 2001, 22 individuals developed anthrax; 5 of the cases were fatal.
During its investigation of the anthrax mailings, the FBI worked with other federal agencies to coordinate and conduct scientific analyses of the anthrax letter spore powders, environmental samples, clinical samples, and samples collected from laboratories that might have been the source of the letter-associated spores. The agency relied on external experts, including some who had developed tests to differentiate among strains of B. anthracis. In 2008, seven years into the investigation, the FBI asked the National Research Council (NRC) of the National Academy of Sciences (NAS) to conduct an independent review of the scientific approaches used during the investigation of the 2001 B. anthracis mailings.
Review of the Scientific Approaches Used During the FBI's Investigation of the Anthrax Letters evaluates the scientific foundation for the techniques used by the FBI to determine whether these techniques met appropriate standards for scientific reliability and for use in forensic validation, and whether the FBI reached appropriate scientific conclusions from its use of these techniques. This report reviews and assesses scientific evidence considered in connection with the 2001 Bacillus anthracis mailings.
Topics: Conflict and Security Issues » Policy, Reviews and Evaluations | Biology and Life Sciences » Policy, Reviews and Evaluations | Math, Chemistry, and Physics » Chemistry | Conflict and Security Issues » Prevention, Security and Response | Conflict and Security Issues » Biosecurity
The polar regions are experiencing rapid changes in climate. These changes are causing observable ecological impacts of various types and degrees of severity at all ecosystem levels, including society. Even larger changes and more significant impacts are anticipated. As species respond to changing environments over time, their interactions with the physical world and other organisms can also change. This chain of interactions can trigger cascades of impacts throughout entire ecosystems. Evaluating the interrelated physical, chemical, biological, and societal components of polar ecosystems is essential to understanding their vulnerability and resilience to climate forcing.
The Polar Research Board (PRB) organized a workshop to address these issues. Experts gathered from a variety of disciplines with knowledge of both the Arctic and Antarctic regions. Participants were challenged to consider what is currently known about climate change and polar ecosystems and to identify the next big questions in the field. A set of interdisciplinary "frontier questions" emerged from the workshop discussions as important topics to be addressed in the coming decades. To begin to address these questions, workshop participants discussed the need for holistic, interdisciplinary systems approach to understanding polar ecosystem responses to climate change. As an outcome of the workshop, participants brainstormed methods and technologies that are crucial to advance the understanding of polar ecosystems and to promote the next generation of polar research. These include new and emerging technologies, sustained long-term observations, data synthesis and management, and data dissemination and outreach.
Topics: Earth Sciences » Polar Studies | Biology and Life Sciences » Genetics
In December 2006, the National Academy of Sciences sponsored a colloquium (featured as part of the Arthur M. Sackler Colloquia series) on "Adaptation and Complex Design" to synthesize recent empirical findings and conceptual approaches toward understanding the evolutionary origins and maintenance of complex adaptations. Darwin's elucidation of natural selection as a creative natural force was a monumental achievement in the history of science, but a century and a half later some religious believers still contend that biotic complexity registers conscious supernatural design. In this book, modern scientific perspectives are presented on the evolutionary origin and maintenance of complex phenotypes including various behaviors, anatomies, and physiologies. After an introduction by the editors and an opening historical and conceptual essay by Francisco Ayala, this book includes 14 papers presented by distinguished evolutionists at the colloquium. The papers are organized into sections covering epistemological approaches to the study of biocomplexity, a hierarchy of topics on biological complexity ranging from ontogeny to symbiosis, and case studies explaining how complex phenotypes are being dissected in terms of genetics and development.
Topics: Biology and Life Sciences » Biology | Biology and Life Sciences » Biodiversity | Biology and Life Sciences » Evolution
A respected resource for decades, the Guide for the Care and Use of Laboratory Animals [updated digital version] has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use:
The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
Topics: Biology and Life Sciences » Laboratory Animal Research | Agriculture » Animal Health and Nutrition | Biology and Life Sciences » Policy, Reviews and Evaluations
The Human Condition is a collection of papers by leading evolutionary biologists and philosophers of science that reflect on the Darwinian Revolution as it relates to the human condition at levels ranging from the molecular to the theological. The book focuses on understanding the evolutionary origin of humans and their biological and cultural traits. The Human Condition is organized into three parts: Human Phylogenetic History and the Paleontological Record; Structure and Function of the Human Genome; and Cultural Evolution and the Uniqueness of Being Human.
This fourth volume from the In the Light of Evolution (ILE) series, based on a series of Arthur M. Sackler colloquia, was designed to promote the evolutionary sciences. Each volume explores evolutionary perspectives on a particular biological topic that is scientifically intriguing but also has special relevance to contemporary societal issues or challenges. Individually and collectively, the ILE series interprets phenomena in various areas of biology through the lens of evolution, addresses some of the most intellectually engaging as well as pragmatically important societal issues of our times, and fosters a greater appreciation of evolutionary biology as a consolidating foundation for the life sciences.
Topics: Biology and Life Sciences » Biodiversity | Biology and Life Sciences » Biology | Biology and Life Sciences » Evolution
Synthetic biology is an innovative and growing field that unites engineering and biology. It builds on the powerful research that came about as a result of a recombinant DNA technology and genome sequencing. By definition, synthetic biology is an interdisciplinary enterprise comprising biologists of many specialties, engineers, physicists, computer scientists and others. It promises a fundamentally deeper understanding of how living systems work and the capacity to recreate them for medicine, public health and the environment, including renewable energy.
NAKFI Synthetic Biology: Building a Nation's Inspiration discusses new foundational technologies and tools required to make biology easier to engineer, considers ethical issues unique to synthetic biology, explores how synthetic biology can lead to an understanding of the principles underlying natural genetic circuits and debates how synthetic biology can be used to answer fundamental biological questions.
Topics: Biology and Life Sciences » Biology | Biology and Life Sciences » Biotechnology
Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multistability, and stochastic behavior—concepts familiar to physicists and chemists—are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior.
Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment.
This book recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions—and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.
Topics: Math, Chemistry, and Physics » Physics | Biology and Life Sciences » Biotechnology | Biology and Life Sciences » Policy, Reviews and Evaluations
The effort to understand and combat infectious diseases has, during the centuries, produced many key advances in science and medicine—including the development of vaccines, drugs, and other treatments. A subset of this research is conducted with agents that, like anthrax, not only pose a severe threat to the health of humans, plants, and animals but can also be used for ill-intended purposes. Such agents have been listed by the government as biological select agents and toxins. The 2001 anthrax letter attacks prompted the creation of new regulations aimed at increasing security for research with dangerous pathogens. The outcome of the anthrax letter investigation has raised concern about whether these measures are adequate.
Responsible Research with Biological Select Agents and Toxins evaluates both the physical security of select agent laboratories and personnel reliability measures designed to ensure the trustworthiness of those with access to biological select agents and toxins. The book offers a set of guiding principles and recommended changes to minimize security risk and facilitate the productivity of research. The book recommends fostering a culture of trust and responsibility in the laboratory, engaging the community in oversight of the Select Agent Program, and enhancing the operation of the Select Agent Program.
Topics: Conflict and Security Issues » Prevention, Security and Response | Biology and Life Sciences » Policy, Reviews and Evaluations | Conflict and Security Issues » Biosecurity
The use of animals in research adheres to scientific and ethical principles that promote humane care and practice. Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare.
Recognition and Alleviation of Pain in Laboratory Animals, the second of two reports revising the 1992 publication Recognition and Alleviation of Pain and Distress in Laboratory Animals from the Institute for Laboratory Animal Research (ILAR), focuses on pain experienced by animals used in research. This book aims to educate laboratory animal veterinarians; students, researchers and investigators; Institutional Animal Care and Use Committee members; and animal care staff and animal welfare officers on the current scientific and ethical issues associated with pain in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines for recognizing and alleviating pain in laboratory animals, focusing specifically on the following areas: physiology of pain in commonly used laboratory species; pharmacologic and non-pharmacologic principles to control pain; identification of humane endpoints; and principles for minimizing pain associated with experimental procedures. Finally, the report identifies areas in which further scientific investigation is needed to improve laboratory animal welfare.
Topics: Biology and Life Sciences » Laboratory Animal Research
Two Centuries of Darwin is the outgrowth of an Arthur M. Sackler Colloquium, sponsored by the National Academy of Sciences on January 16-17, 2009. In the chapters of this book, leading evolutionary biologists and science historians reflect on and commemorate the Darwinian Revolution. They canvass modern research approaches and current scientific thought on each of the three main categories of selection (natural, artificial, and sexual) that Darwin addressed during his career. Although Darwin's legacy is associated primarily with the illumination of natural selection in The Origin, he also contemplated and wrote extensively about what we now term artificial selection and sexual selection. In a concluding section of this book, several science historians comment on Darwin's seminal contributions.
Two Centuries of Darwin is the third book of the In the Light of Evolution series. Each installment in the series explores evolutionary perspectives on a particular biological topic that is scientifically intriguing but also has special relevance to contemporary societal issues or challenges. The ILE series aims to interpret phenomena in various areas of biology through the lens of evolution and address some of the most intellectually engaging, as well as pragmatically important societal issues of our times.
Topics: Biology and Life Sciences » Evolution | Biology and Life Sciences » Biodiversity | Biology and Life Sciences » Biology | Explore Science » Explore Science
Scientific and Humane Issues in the Use of Random-Source Dogs and Cats in Research examines the value of random-source animals in biomedical research and the role of Class B dealers who acquire and resell live dogs and cats to research institutions. Findings include that, while some random-source dogs and cats may be necessary and desirable for National Institutes of Health (NIH)-funded research, there is no clear need to obtain those animals from Class B dealers. Several options for random-source animal acquisition already exist and additional options are recommended, which would further ensure the welfare of these animals and foster a positive public image for NIH.
While the scientific community has recognized and responded to concerns for humane treatment of animals in research, government oversight has thus far been unable to fully enforce the Animal Welfare Act in regard to Class B dealers of live animals. Although the animals acquired by Class B dealers are destined for research—and NIH research in particular—the standard of care while in the possession of some Class B dealers requires an inordinate amount of government enforcement and is not commensurate with the policies of most NIH-funded research laboratories. This dichotomy of standards reflects poorly on public perceptions of NIH and jeopardizes animal welfare.
This book will be crucial for NIH and other groups using random-source animals in research, including veterinary schools and research facilities. Animal welfare advocates, policy makers, and concerned pet owners will also find this a vital and informative work for reconciling the needs of research with the welfare of animals.
Topics: Biology and Life Sciences » Laboratory Animal Research | Agriculture » Animal Health and Nutrition
The same technologies that fuel scientific advances also pose potential risks—that the knowledge, tools, and techniques gained through legitimate biotechnology research could be misused to create biological weapons or for bioterrorism. This is often called the dual use dilemma of the life sciences. Yet even research with the greatest potential for misuse may offer significant benefits. Determining how to constrain the danger without harming essential scientific research is critical for national security as well as prosperity and well-being.
This book discusses a 2007 survey of American Association for the Advancement of Science (AAAS) members in the life sciences about their knowledge of dual use issues and attitudes about their responsibilities to help mitigate the risks of misuse of their research.
Overall, the results suggest that there may be considerable support for approaches to oversight that rely on measures that are developed and implemented by the scientific community itself. The responses also suggest that there is a need to clarify the scope of research activities of concern and to provide guidance about what actions scientists can take to reduce the risk that their research will be misused by those with malicious intent.
Topics: Policy for Science and Technology » Policy for Science and Technology | Biology and Life Sciences » Policy, Reviews and Evaluations | Conflict and Security Issues » Policy, Reviews and Evaluations | Conflict and Security Issues » Prevention, Security and Response | Conflict and Security Issues » Biosecurity
The current extinction crisis is of human making, and any favorable resolution of that biodiversity crisis—among the most dire in the 4-billion-year history of Earth—will have to be initiated by mankind. Little time remains for the public, corporations, and governments to awaken to the magnitude of what is at stake. This book aims to assist that critical educational mission, synthesizing recent scientific information and ideas about threats to biodiversity in the past, present, and projected future.
This is the second volume from the In the Light of Evolution series, based on a series of Arthur M. Sackler colloquia, and designed to promote the evolutionary sciences. Each installment explores evolutionary perspectives on a particular biological topic that is scientifically intriguing but also has special relevance to contemporary societal issues or challenges. Individually and collectively, the ILE series aims to interpret phenomena in various areas of biology through the lens of evolution, address some of the most intellectually engaging as well as pragmatically important societal issues of our times, and foster a greater appreciation of evolutionary biology as a consolidating foundation for the life sciences.
Topics: Biology and Life Sciences » Biodiversity | Biology and Life Sciences » Genetics | Biology and Life Sciences » Evolution
Since the first commercial introduction of transgenic corn plants in 1995, biotechnology has provided enormous benefits to agricultural crop production. Research is underway to develop a much broader range of genetically engineered organisms (GEOs), including fish, trees, microbes, and insects, that could have the potential to transform fields such as aquaculture, biofuels production, bioremediation, biocontrol, and even the production of pharmaceuticals . However, biotechnology is not without risk and continues to be an extremely controversial topic. Chief among the concerns is the potential ecological effects of GEOs that interact with wildlife and habitats.
The U.S. Geological Survey (USGS) is charged with providing scientific advice to inform federal agencies that manage wildlife and their habitats. USGS has identified biotechnology as one of its major challenges for future research. Seeing an opportunity to initiate a dialogue between ecologists and developers of GEOs about this challenge, the USGS and the National Research Council (NRC) held a two-day workshop in November of 2007, to identify research activities with the greatest potential to provide the information needed to assess the ecological effects of GEOs on wildlife and habitats. The workshop, designed to approach the research questions from a habitat, rather than transgenic organism, perspective, is summarized in this book.
Topics: Agriculture » Crop and Plant Production | Environment and Environmental Studies » Ecology and Ecosystems | Biology and Life Sciences » Genetics
Topics: Biology and Life Sciences » Biotechnology | Biology and Life Sciences » Policy, Reviews and Evaluations
Life on Earth would be impossible without plants. Humans rely on plants for most clothing, furniture, food, as well as for many pharmaceuticals and other products. Plant genome sciences are essential to understanding how plants function and how to develop desirable plant characteristics. For example, plant genomic science can contribute to the development of plants that are drought-resistant, those that require less fertilizer, and those that are optimized for conversion to fuels such as ethanol and biodiesel. The National Plant Genome Initiative (NPGI) is a unique, cross-agency funding enterprise that has been funding and coordinating plant genome research successfully for nine years. Research breakthroughs from NPGI and the National Science Foundation (NSF) Arabidopsis 2010 Project, such as how the plant immune system controls pathogen defense, demonstrate that the plant genome science community is vibrant and capable of driving technological advancement. This book from the National Research Council concludes that these programs should continue so that applied programs on agriculture, bioenergy, and others will always be built on a strong foundation of fundamental plant biology research.
Topics: Biology and Life Sciences » Policy, Reviews and Evaluations | Biology and Life Sciences » Genetics | Agriculture » Policy, Reviews and Evaluations | Agriculture » Crop and Plant Production
Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. This new book from the Institute for Laboratory Animal Research (ILAR) at the National Research Council, Recognition and Alleviation of Distress in Laboratory Animals, focuses on the stress and distress which is experienced by animals when used in laboratory research. This book aims to educate laboratory animal veterinarians; students, researchers, and investigators; animal care staff, as well as animal welfare officers on the current scientific and ethical issues associated with stress and distress in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines. Recognition and Alleviation of Distress in Laboratory Animals focuses specifically on the scientific understanding of the causes and the functions of stress and distress, the transformation of stress to distress, and the identification of principles for the recognition and alleviation of distress. This book discusses the role of humane endpoints in situations of distress and principles for the minimization of distress in laboratory animals. It also identifies areas in which further scientific investigation is needed to improve laboratory animal welfare in order to adhere to scientific and ethical principles that promote humane care and practice.
Topics: Biology and Life Sciences » Laboratory Animal Research
Topics: Agriculture » Crop and Plant Production | Biology and Life Sciences » Animals, Plants and Other Organisms
Although its importance is not always recognized, theory is an integral part of all biological research. Biologists' theoretical and conceptual frameworks inform every step of their research, affecting what experiments they do, what techniques and technologies they develop and use, and how they interpret their data.
By examining how theory can help biologists answer questions like "What are the engineering principles of life?" or "How do cells really work?" the report shows how theory synthesizes biological knowledge from the molecular level to the level of whole ecosystems. The book concludes that theory is already an inextricable thread running throughout the practice of biology; but that explicitly giving theory equal status with other components of biological research could help catalyze transformative research that will lead to creative, dynamic, and innovative advances in our understanding of life.
Topics: Biology and Life Sciences » Biology | Biology and Life Sciences » Biotechnology
How did life evolve on Earth? The answer to this question can help us understand our past and prepare for our future. Although evolution provides credible and reliable answers, polls show that many people turn away from science, seeking other explanations with which they are more comfortable.
In the book Science, Evolution, and Creationism, a group of experts assembled by the National Academy of Sciences and the Institute of Medicine explain the fundamental methods of science, document the overwhelming evidence in support of biological evolution, and evaluate the alternative perspectives offered by advocates of various kinds of creationism, including "intelligent design." The book explores the many fascinating inquiries being pursued that put the science of evolution to work in preventing and treating human disease, developing new agricultural products, and fostering industrial innovations. The book also presents the scientific and legal reasons for not teaching creationist ideas in public school science classes.
Mindful of school board battles and recent court decisions, Science, Evolution, and Creationism shows that science and religion should be viewed as different ways of understanding the world rather than as frameworks that are in conflict with each other and that the evidence for evolution can be fully compatible with religious faith. For educators, students, teachers, community leaders, legislators, policy makers, and parents who seek to understand the basis of evolutionary science, this publication will be an essential resource.
Topics: Biology and Life Sciences » Biology | Education » Math and Science Education | Biology and Life Sciences » Evolution
Topics: Math, Chemistry, and Physics » Physics | Biology and Life Sciences » Biotechnology
Pollinators—insects, birds, bats, and other animals that carry pollen from the male to the female parts of flowers for plant reproduction—are an essential part of natural and agricultural ecosystems throughout North America. For example, most fruit, vegetable, and seed crops and some crops that provide fiber, drugs, and fuel depend on animals for pollination.
This report provides evidence for the decline of some pollinator species in North America, including America's most important managed pollinator, the honey bee, as well as some butterflies, bats, and hummingbirds. For most managed and wild pollinator species, however, population trends have not been assessed because populations have not been monitored over time. In addition, for wild species with demonstrated declines, it is often difficult to determine the causes or consequences of their decline. This report outlines priorities for research and monitoring that are needed to improve information on the status of pollinators and establishes a framework for conservation and restoration of pollinator species and communities.
Topics: Agriculture » Crop and Plant Production | Biology and Life Sciences » Genetics | Agriculture » Animal Health and Nutrition | Biology and Life Sciences » Animals, Plants and Other Organisms
This report is the second in a series of three evaluating underexploited African plant resources that could help broaden and secure Africa's food supply. The volume describes the characteristics of 18 little-known indigenous African vegetables (including tubers and legumes) that have potential as food- and cash-crops but are typically overlooked by scientists and policymakers and in the world at large. The book assesses the potential of each vegetable to help overcome malnutrition, boost food security, foster rural development, and create sustainable landcare in Africa. Each species is described in a separate chapter, based on information gathered from and verified by a pool of experts throughout the world. Volume I describes African grains and Volume III African fruits.
Topics: Agriculture » Crop and Plant Production | Biology and Life Sciences » Animals, Plants and Other Organisms
Mimi Koehl tinkers with machines. Some are so tiny they can't be seen by the naked eye, and some disappeared millions of years ago. But Mimi isn't a mechanic. She's a biomechanist. Mimi Koehl uses engineering and physics to study the designs of living things that fly, swim, drift, and crawl. She loves solving riddles about how creatures—from feathered dinosaurs to flying frogs—live and move. Mimi's curiosity has led her into all kinds of natural neighborhoods. She has braved turbulent waters to explore how giant green sea anemones survive crashing waves. In Chile, while studying seaweeds, a rogue wave washed Mimi off one cliff and slammed her into another one. But nothing stops her desire for discovery. To uncover answers, Mimi has attached leashes to microscopic animals and created ingenious models using raspberry gelatin and even Silly Putty. Today Mimi searches the world—and her imagination—for answers to life's challenging mysteries.
This title aligns to Common Core standards:
Interest Level Grades 6 - 8; Reading Level Grade level Equivalent: 7.1: Lexile Measure: 1080L; DRA: Not Available; Guided Reading: Z
Topics: Explore Science » Explore Science | Biology and Life Sciences » Animals, Plants and Other Organisms | » Biography and Autobiography
Amy Vedder leads a wild life. How many people can say they were once a member of a mountain gorilla family? Amy Vedder is a wildlife biologist, a scientist who studies animals and their behavior. She uses her knowledge to save animals whose lives and habitats are threatened. She once lived in a remote part of central Africa, where she helped rescue Rwanda's mountain gorillas from extinction. Amy did groundbreaking science in a beautiful rain forest environment, but it wasn't always easy. She had to face tough conditions in a country affected by conflict and war. In the process, she met unforgettable people and unforgettable gorillas. Today Amy travels the world, from her home base at New York's Bronx Zoo to the far reaches of Mongolia in Asia. Everywhere she goes, she teaches people how to appreciate and protect the precious wildlife that surrounds them. Gorilla Mountain is an exciting and inspiring story of true tale adventure. Young readers everywhere will be moved by the story of the young nature lover who became a powerful champion of great apes.
This title aligns to Common Core standards:
Interest Level Grades 6 - 8; Reading Level Grade level Equivalent: 7.1: Lexile Measure: 1080L; DRA: Not Available; Guided Reading: Z
Topics: Explore Science » Explore Science | Biology and Life Sciences » Animals, Plants and Other Organisms | » Biography and Autobiography | Biography and Autobiography » Biographies
The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies—including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID)—be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.
Topics: Conflict and Security Issues » Policy, Reviews and Evaluations | Biology and Life Sciences » Laboratory Animal Research | Conflict and Security Issues » Biosecurity
Topics: Biology and Life Sciences » Laboratory Animal Research | Agriculture » Animal Health and Nutrition
Biomedical advances have made it possible to identify and manipulate features of living organisms in useful ways—leading to improvements in public health, agriculture, and other areas. The globalization of scientific and technical expertise also means that many scientists and other individuals around the world are generating breakthroughs in the life sciences and related technologies. The risks posed by bioterrorism and the proliferation of biological weapons capabilities have increased concern about how the rapid advances in genetic engineering and biotechnology could enable the production of biological weapons with unique and unpredictable characteristics. Globalization, Biosecurity, and the Future of Life Sciences examines current trends and future objectives of research in public health, life sciences, and biomedical science that contain applications relevant to developments in biological weapons 5 to 10 years into the future and ways to anticipate, identify, and mitigate these dangers.
Topics: Biology and Life Sciences » Biotechnology | Conflict and Security Issues » Prevention, Security and Response | Policy for Science and Technology » Policy for Science and Technology | Conflict and Security Issues » Biosecurity
Topics: Agriculture » Animal Health and Nutrition | Biology and Life Sciences » Laboratory Animal Research
Topics: Biology and Life Sciences » Policy, Reviews and Evaluations | Biology and Life Sciences » Biotechnology | Policy for Science and Technology » Research and Data
Science, Medicine, and Animals explains the role that animals play in biomedical research and the ways in which scientists, governments, and citizens have tried to balance the experimental use of animals with a concern for all living creatures. An accompanying Teacher's Guide is available to help teachers of middle and high school students use Science, Medicine, and Animals in the classroom. As students examine the issues in Science, Medicine, and Animals, they will gain a greater understanding of the goals of biomedical research and the real-world practice of the scientific method in general.
Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network.
Science, Medicine, and Animals is recommended by the National Science Teacher's Association NSTA Recommends.
Topics: Biology and Life Sciences » Laboratory Animal Research | Education » Math and Science Education | Education » Teacher Preparation and Professional Development
Topics: Biology and Life Sciences » Biotechnology | Computers and Information Technology » Computers | Biology and Life Sciences » Biology | Math, Chemistry, and Physics » Math and Statistics | Math, Chemistry, and Physics » Physics | Math, Chemistry, and Physics » Chemistry | Surveys and Statistics » Surveys and Statistics
Animal Health at the Crossroads: Preventing, Detecting, and Diagnosing Animal Diseases finds that, in general, the U.S. animal health framework has been slow to take advantage of state-of-the-art technologies being used now to protect public health; better diagnostic tests for identifying all animal diseases should be made a priority. The report also recommends that the nation establish a high-level, authoritative, and accountable coordinating mechanism to engage and enhance partnerships among local, state, and federal agencies, and the private sector.
Topics: Agriculture » Animal Health and Nutrition | Biology and Life Sciences » Animals, Plants and Other Organisms
Topics: Agriculture » Animal Health and Nutrition | Biology and Life Sciences » Animals, Plants and Other Organisms | Biology and Life Sciences » Policy, Reviews and Evaluations
In addition to a preceding essay by Edward O. Wilson, this book includes the 16 papers presented by distinguished evolutionists at the colloquium. The papers are organized into sections covering the origins of species barriers, the processes of species divergence, the nature of species, the meaning of "species," and genomic approaches for understanding diversity and speciation.
Topics: Biology and Life Sciences » Biology | Biology and Life Sciences » Biodiversity
News reports concerning decline of the world's forests are becoming sadly familiar. Most losses are measured in square kilometers, but a more profound loss cannot be measured. As forests disappear, so do their genetic resources. The genes they possess can no longer aid in their adaptation to a changing environment, nor can they be used to develop improved varieties or products.
This book assesses the status of the world's tree genetic resources and management efforts. Strategies for meeting future needs and alternatives to harvesting natural forests are presented. The book also outlines methods and technologies for management, evaluates activities now under way, and makes specific recommendations for a global strategy for forest management.
Topics: Biology and Life Sciences » Genetics | Earth Sciences » Forestry
Since 1941, Recommended Dietary Allowances (RDAs) has been recognized as the most authoritative source of information on nutrient levels for healthy people. Since publication of the 10th edition in 1989, there has been rising awareness of the impact of nutrition on chronic disease. In light of new research findings and a growing public focus on nutrition and health, the expert panel responsible for formulation RDAs reviewed and expanded its approach—the result: Dietary Reference Intakes.
This new series of references greatly extends the scope and application of previous nutrient guidelines. For each nutrient the book presents what is known about how the nutrient functions in the human body, what the best method is to determine its requirements, which factors (caffeine or exercise, for example) may affect how it works, and how the nutrient may be related to chronic disease.
This volume of the series presents information about thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline.
Based on analysis of nutrient metabolism in humans and data on intakes in the U.S. population, the committee recommends intakes for each age group—from the first days of life through childhood, sexual maturity, midlife, and the later years. Recommendations for pregnancy and lactation also are made, and the book identifies when intake of a nutrient may be too much. Representing a new paradigm for the nutrition community, Dietary Reference Intakes encompasses:
This new framework encompasses both essential nutrients and other food components thought to pay a role in health, such as dietary fiber. It incorporates functional endpoints and examines the relationship between dose and response in determining adequacy and the hazards of excess intake for each nutrient.
Topics: Food and Nutrition » Nutrition - Dietary Reference Intakes | Biology and Life Sciences » Laboratory Animal Research
This book assesses the scientific value and merit of research on human genetic differences—including a collection of DNA samples that represents the whole of human genetic diversity—and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.
Topics: Biology and Life Sciences » Genetics | Behavioral and Social Sciences » Population Studies
Matching DNA samples from crime scenes and suspects is rapidly becoming a key source of evidence for use in our justice system. DNA Technology in Forensic Science offers recommendations for resolving crucial questions that are emerging as DNA typing becomes more widespread.
The volume addresses key issues:
Combining this original volume with the new update—The Evaluation of Forensic DNA Evidence—provides the complete, up-to-date picture of this highly important and visible topic.
This volume offers important guidance to anyone working with this emerging law enforcement tool: policymakers, specialists in criminal law, forensic scientists, geneticists, researchers, faculty, and students.
Topics: Biology and Life Sciences » Genetics
Biotechnology offers tremendous potential for improving crop production, animal agriculture, and bioprocessing. It can provide scientists with new ways to develop higher-yielding and more nutritious crop varieties, to improve resistance to disease, or to reduce the need for inputs of fertilizers and other expensive agricultural chemicals. This book explores the United States' ability to solve important agricultural problems, effectively use funds and institutional structures to support biotechnology research for agriculture, train researchers in new scientific areas, efficiently transfer technology, and regulate and test recombinant DNA organisms in the field.
Topics: Agriculture » Crop and Plant Production | Biology and Life Sciences » Biotechnology
Clear guidelines on the proper care and use of laboratory animals are being sought by researchers and members of the many committees formed to oversee animal care at universities as well as the general public. This book provides a comprehensive overview of what we know about behavior, pain, and distress in laboratory animals.
The volume explores:
Also included is a highly practical, extensive listing, by species, of dosages and side effects of anesthetics, analgesics, and tranquilizers.
Topics: Biology and Life Sciences » Laboratory Animal Research
Care and use of animals in research are expensive, prompting efforts to contain or reduce costs. Components of those costs are personnel, regulatory compliance, veterinary medical care, and laboratory animal management, equipment, and procedures. Many efforts have been made to control and reduce personnel costs, the largest contributing factor to cost, through better facility and equipment design, more efficient use of personnel, and automation of many routine operations. However, there has been no comprehensive, recent analysis of the various cost components or examination of the strategies that have been proven or are purported to decrease the cost of animal facility operation.
Strategies that Influence Cost Containment in Animal Research Facilities examines the current interpretation of governmental policy (Office of Management and Budget Circular A-21) concerning institutional reimbursement for overhead costs of an animal research facility and describes methods for economically operating an animal research facility. This report develops recommendations by which federal auditors and research institutions can establish what cost components of research animal facilities should be charged to institutions' indirect cost pool and what animal research facility cost components should be included in the per diem charges to investigators, and assesses the financial and scientific ramifications that these criteria would have among federally funded institutions. Further, the report determines the cost components of laboratory animal care and use in biomedical research and assesses and recommends methods of cost containment for institutions maintaining animals for biomedical research.
Topics: Engineering and Technology » Construction: Design, Research, Planning | Biology and Life Sciences » Laboratory Animal Research
"The book...is, in fact, a short text on the many practical problems...associated with translating the explosion in basic biotechnological research into the next Green Revolution," explains Economic Botany. The book is "a concise and accurate narrative, that also manages to be interesting and personal...a splendid little book." Biotechnology states, "Because of the clarity with which it is written, this thin volume makes a major contribution to improving public understanding of genetic engineering's potential for enlarging the world's food supply...and can be profitably read by practically anyone interested in application of molecular biology to improvement of productivity in agriculture."
Topics: Biology and Life Sciences » Genetics
Environmental Effects of Transgenic Plants provides a wealth of information about transgenic processes, previous experience with the introduction of novel crops, principles of risk assessment and management, the science behind current regulatory schemes, issues in monitoring transgenic products already on the market, and more.
The book discusses public involvement—and public confidence—in biotechnology regulation. And it looks to the future, exploring the potential of genetic engineering and the prospects for environmental effects.
Topics: Agriculture » Crop and Plant Production | Biology and Life Sciences » Biotechnology
Topics: Policy for Science and Technology » Policy for Science and Technology | Biology and Life Sciences » Biotechnology
Endangered and Threatened Species of the Platte River addresses the habitat requirements for these federally protected species. The book further examines the scientific aspects of the U.S. Fish and Wildlife Service's instream-flow recommendations and habitat suitability guidelines and assesses the science concerning the connections among the physical systems of the river as they relate to species' habitats.
Topics: Earth Sciences » Ecology and Ecosystems | Environment and Environmental Studies » Ecology and Ecosystems | Biology and Life Sciences » Animals, Plants and Other Organisms
Advances in science and engineering increasingly require the collaboration of scholars from various fields. This shift is driven by the need to address complex problems that cut across traditional disciplines, and the capacity of new technologies to both transform existing disciplines and generate new ones. At the same time, however, interdisciplinary research can be impeded by policies on hiring, promotion, tenure, proposal review, and resource allocation that favor traditional disciplines.
This report identifies steps that researchers, teachers, students, institutions, funding organizations, and disciplinary societies can take to more effectively conduct, facilitate, and evaluate interdisciplinary research programs and projects. Throughout the report key concepts are illustrated with case studies and results of the committee's surveys of individual researchers and university provosts.
Topics: Policy for Science and Technology » Research and Data | Biology and Life Sciences » Biology
This volume is an indispensable reference on the nature of immune defects in rodents and the special techniques necessary to maintain and breed them. The authors describe 64 inbred, hybrid, and mutant strains of rodents, each with some immune defect; explain mechanisms for ensuring genetic purity; and provide a standardized nomenclature for different varieties. Subsequent sections summarize and provide references on the genetics, pathophysiology, husbandry, and reproduction of each of the various strains as well as sound advice on planning for the selection, transportation, housing, and maintenance of these animals.
Topics: Biology and Life Sciences » Laboratory Animal Research
This volume reviews the current state of knowledge regarding the effects of low-frequency sound on marine mammals and makes recommendations for research. In addition, the book describes current federal regulations prescribed under the Marine Mammal Protection Act that govern the taking of marine mammals by scientific research activities, and it recommends changes to expedite the regulatory process dealing with scientific research activities.
Topics: Biology and Life Sciences » Animals, Plants and Other Organisms
Much has been written about the care of research animals. Yet little guidance has appeared on protecting the health and safety of the people who care for or use these animals.
This book, an implementation handbook and companion to Guide For the Care and Use of Laboratory Animals, identifies principles for building a program and discusses the accountability of institutional leaders, managers, and employees for a program's success. It provides a detailed description of risks—physical and chemical hazards, allergens and zoonoses, and hazards from experiments—which will serve as a continuing reference for the laboratory.
The book offers specific recommendations for controlling risk through administrative procedures, facility design, engineering controls, and periodic evaluations. The volume focuses on the worker, with detailed discussions of work practices, the use of personal protective gear, and the development of an emergency response plan.
This handbook will be invaluable to administrators, researchers, and employees in any animal research facility. It will also be of interest to personnel in zoos, animal shelters, and veterinary facilities.
Topics: Biology and Life Sciences » Laboratory Animal Research
Do persons exposed to radiation suffer genetic effects that threaten their yet-to-be-born children? Researchers are concluding that the genetic risks of radiation are less than previously thought.
This finding is explored in this volume about the children of atomic bomb survivors in Hiroshima and Nagasaki—the population that can provide the greatest insight into this critical issue. Assembled here for the first time are papers representing more than 40 years of research. These documents reveal key results related to radiation's effects on pregnancy termination, sex ratio, congenital defects, and early mortality of children. Edited by two of the principal architects of the studies, J. V. Neel and W. J. Schull, the volume also offers an important comparison with studies of the genetic effects of radiation on mice.
The wealth of technical details will be immediately useful to geneticists and other specialists. Policymakers will be interested in the overall conclusions and discussion of future studies.
Topics: Biology and Life Sciences » Genetics
The Endangered Species Act (ESA) is a far-reaching law that has sparked intense controversies over the use of public lands, the rights of property owners, and economic versus environmental benefits. In this volume a distinguished committee focuses on the science underlying the ESA and offers recommendations for making the act more effective.
Topics: Environment and Environmental Studies » Ecology and Ecosystems | Biology and Life Sciences » Animals, Plants and Other Organisms
Sound has become a major tool for studying the ocean. Although the ocean is relatively opaque to light, it is relatively transparent to sound. Sound having frequencies below 1,000 Hertz (Hz) is often defined as low-frequency sound. The speed of sound is proportional to the temperature of the water through which it passes. Therefore, sound speed can be used to infer the average temperature of the water volume through which sound waves have passed. The relationship between water temperature and the speed of sound is the basis for the Acoustic Thermometry of Ocean Climate (ATOC) experiment. The ATOC experiment is designed to monitor the travel time of sound between sources off the coasts of Hawaii and California and several receivers around the Pacific Ocean in order to detect trends in ocean temperature and for other research and monitoring purposes.
Some whales, seals, and fish use low-frequency sound to communicate and to sense their environments. For example, baleen whales and some toothed whales are known to use and respond to low-frequency sound emitted by other individuals of their species. Sharks are not known to produce low-frequency sound but are attracted to pulsed low-frequency sounds. Therefore, it is possible that human-generated low-frequency sound could interfere with the natural behavior of whales, sharks, and some other marine animals.
Marine Mammals and Low-Frequency Sound is an updated review of the National Research Council 1994 report Low-Frequency Sound and Marine Mammals: Current Knowledge and Research Needs, based on data obtained from the MMRP and results of any other relevant research, including ONR's research program in low-frequency sound and marine mammals. This report compares new data with the research needs specified in the 1994 NRC report, focusing on the strengths and weaknesses of the data for answering important outstanding questions about marine mammal responses to low-frequency sound and identifies areas where gaps in our knowledge continue to exist.
Topics: Biology and Life Sciences » Animals, Plants and Other Organisms | Earth Sciences » Ocean Studies
In this first in a proposed series of workshops on regulatory issues in animal care and use, the Institute for Laboratory Animal Research (ILAR) has addressed the existing and proposed requirements for reporting pain and distress in laboratory animals. The Animal Welfare Act, administered by the Animal and Plant Health Inspection Service of the United States Department of Agriculture (USDA), mandates that pain and distress in laboratory animals be minimized. USDA is considering two policy changes with regard to this specific mandate. Firstly, since there has been no functional definition of "distress," USDA has prepared such a definition and requested feedback from the scientific community on its usefulness for regulatory and reporting requirements.
The second issue concerns the pain and distress categorization scheme for reporting to USDA. Various groups and individuals have questioned the efficacy of the current categories, and specific changes have been proposed by the Humane Society of the United States. USDA is considering these and other potential changes to the existing scheme. Thus, given these potential changes to animal welfare policy, the aim of the ILAR/NIH joint workshop was to provide feedback to the USDA. The speakers were asked to address these two issues as well as to comment upon whether the information contained in the 1992 ILAR report Recognition and Alleviation of Pain and Distress in Laboratory Animals is still useful to investigators in assisting them to comply with regulations. The speakers provided perspectives based on their individual expertise in the areas of science of pain and distress, animal welfare policy, protocol review, and/or as representatives of relevant organizations or institutions. The following proceedings are an edited transcript of their presentations.
Topics: Biology and Life Sciences » Laboratory Animal Research
Authored by an integrated committee of plant and animal scientists, this review of newer molecular genetic techniques and traditional research methods is presented as a compilation of high-reward opportunities for agricultural research. Directed to the Agricultural Research Service and the agricultural research community at large, the volume discusses biosciences research in genetic engineering, animal science, plant science, and plant diseases and insect pests. An optimal climate for productive research is discussed.
Topics: Agriculture » Crop and Plant Production | Biology and Life Sciences » Biotechnology
Topics: Environment and Environmental Studies » Ecology and Ecosystems | Biology and Life Sciences » Animals, Plants and Other Organisms
Topics: Biology and Life Sciences » Genetics | Earth Sciences » Polar Studies
In 1988 the U.S. Fish and Wildlife Service listed two endemic fishes of the upper Klamath River basin of Oregon and California, the sucker and the Lost River sucker, as endangered under the federal Endangered Species Act (ESA). In 1997, the National Marine Fisheries Service added the Southern Oregon Northern coastal California (SONCC) coho salmon as a threatened species to the list. The leading factors attributed to the decline of these species were overfishing, blockage of migration, entrainment by water management structures, habitat degradation, nonnative species, and poor water quality.
Endangered and Threatened Fishes of the Klamath River Basin addresses the scientific aspects related to the continued survival of coho salmon and shortnose and Lost River suckers in the Klamath River. The book further examines and identifies gaps in the knowledge and scientific information needed for recovery of the listed species and proves an assessment of scientific considerations relevant to strategies for promoting the recovery of those species.
Topics: Environment and Environmental Studies » Ecology and Ecosystems | Agriculture » Aquaculture and Fisheries | Biology and Life Sciences » Animals, Plants and Other Organisms
Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network.
Science, Medicine, and Animals is recommended by the National Science Teacher's Association.
Topics: Biology and Life Sciences » Animals, Plants and Other Organisms | Biology and Life Sciences » Laboratory Animal Research
Toxicogenomics, the study of how genomes respond to exposure to toxicants, may ultimately hold the promise of detecting changes in the expression of a person's genes if he or she is exposed to these toxicants. As the technology rapidly develops, it is critical that scientists and the public communicate about the promises and limitations of this new field. Communicating technical information to the public about a developing science can be challenging, particularly when the applications of that science are not yet well understood.
Communicating Toxicogenomics Information to Nonexperts is the summary of a workshop designed to consider strategies for communicating toxicogenomic information to the public and other non- expert audiences, specifically addressing the communication of some key social, ethical, and legal issues related to toxicogenomics and addressing how information related to the social implications of toxicogenomics might be perceived by nonexperts.
Topics: Biology and Life Sciences » Genetics | Environment and Environmental Studies » Pollutants and Toxics
This book results from a study by a committee of the Institute of Medicine and the National Research Council's Board on Agriculture. The committee examined the scientific foundations of medically assisted conception and developed an agenda for basic research in reproductive and developmental biology that would contribute to advances in the clinical and agricultural practice of in vitro fertilization and embryo transfer. The volume also discusses some barriers to progress in research and ways of lowering them, and explains the scientific issues important to ethical decision making.
Topics: Biology and Life Sciences » Biology | Health and Medicine » Health Sciences
From earliest times, human beings have noticed patterns in nature: night and day, tides and lunar cycles, the changing seasons, plant succession, and animal migration. While recognizing patterns conferred great survival advantage, we are now in danger from our own success in multiplying our numbers and altering those patterns for our own purposes.
It is imperative that we engage again with the patterns of nature, but this time, with awareness of our impact as a species. How will burgeoning human populations affect the health of ecosystems? Is loss of species simply a regrettable byproduct of human expansion? Or is the planet passing into a new epoch in just a few human generations?
Nature and Human Society presents a wide-ranging exploration of these and other fundamental questions about our relationship with the environment. This book features findings, insights, and informed speculations from key figures in the field: E.O. Wilson, Thomas Lovejoy, Peter H. Raven, Gretchen Daily, David Suzuki, Norman Myers, Paul Erlich, Michael Bean, and many others.
This volume explores the accelerated extinction of species and what we stand to lose—medicines, energy sources, crop pollination and pest control, the ability of water and soil to renew itself through biological processes, aesthetic and recreational benefits—and how these losses may be felt locally and acutely.
What are the specific threats to biodiversity? The book explores human population growth, the homogenization of biota as a result in tourism and trade, and other factors, including the social influences of law, religious belief, and public education.
Do we have the tools to protect biodiversity? The book looks at molecular genetics, satellite data, tools borrowed from medicine, and other scientific techniques to firm up our grasp of important processes in biology and earth science, including the "new" science of conservation biology.
Nature and Human Society helps us renew our understanding and appreciation for natural patterns, with surprising details about microorganisms, nematodes, and other overlooked forms of life: their numbers, pervasiveness, and importance to the health of the soil, water, and air and to a host of human endeavors.
This book will be of value to anyone who believes that the world's gross natural product is as important as the world's gross national product.
Topics: Environment and Environmental Studies » Sustainable Development | Biology and Life Sciences » Biology | Environment and Environmental Studies » Ecology and Ecosystems