New From NAP

Obesity Prevention Four-Volume Set

Tue, 15 May 2012 17:00:01 EST

The Obesity Prevention Four-Volume Set is a collection of titles that explain current obesity-prevention strategies and identifies recommendations to accelerate progress in preventing this epidemic. The titles in this collection include: Local Government Actions to prevent Childhood Obesity, Bridging the Evidence Gap in Obesity Prevention: A Framework to Inform Decision Making, Early Childhood Obesity Prevention Policies, Accelerating Progress in Obesity Prevention: Solving the Weight of the Nation.

Local Government Actions to Prevent Childhood Obesity explains a number of recommendations that touch on the vital role of government actions on all levels-federal, state, and local-in childhood obesity prevention. The book offers healthy eating and physical activity strategies for local governments to consider, making it an excellent resource for mayors, managers,commissioners, council members, county board members, and administrators.

Bridging the Evidence Gap in Obesity Prevention: A Framework to Inform Decision Making presents useful data on the effectiveness of obesity prevention policies and programs to battle the obesity epidemic in America that health care professionals and policymakers need. This book identifies a new approach to decision making and research on obesity prevention to use a systems perspective to gain a broader understanding of the context of obesity and the many factors that influence it.

Early Childhood Obesity Prevention Policies reviews factors related to overweight and obese children from infants to young children. Focusing on nutrition, physical activity, and sedentary behavior, this book recommends policies that can alter children's environments to promote the maintenance of healthy weight. Because the first years of life are important to health and well-being throughout the life span, preventing obesity in infants and young children can contribute to reversing the epidemic of obesity in children and adults. This book suggests that parents and child care providers keep children active throughout the day, provide them with healthy diets, limit screen time, and ensure children get adequate sleep.

Accelerating Progress in Obesity Prevention: Solving the Weight of the Nation addresses obesity's effects on health, health care costs, and our productivity as a nation. In this book, The Institute of Medicine (IOM) evaluated prior obesity-prevention strategies and identified recommendations to accelerate progress. The IOM's recommendations, when implemented together, could profoundly reshape the environments where people live, learn, work, and play. The recommendations can inform the decisions of state and local child care regulators, child care providers, health care providers, directors of federal and local child care and nutrition programs, and government officials at all levels.

Using American Community Survey Data to Expand Access to the School Meals Program

Tue, 15 May 2012 17:00:01 EST

The National School Lunch and School Breakfast Programs, administered by the Food and Nutrition Service (FNS) of the U.S. Department of Agriculture (USDA), are key components of the nation's food security safety net, providing free or low-cost meals to millions of schoolchildren each day. To qualify their children each year for free or reduced-price meals, many families must submit applications that school officials distribute and review. To reduce this burden on families and schools and to encourage more children to partake of nutritious meals, USDA regulations allow school districts to operate their meals programs under special provisions that eliminate the application process and other administrative procedures in exchange for providing free meals to all students enrolled in one or more school in a district.

FNS asked the National Academies' Committee on National Statistics and Food and Nutrition Board to convene a panel of experts to investigate the technical and operational feasibility of using data from the continuous American Community Survey (ACS) to estimate students eligible for free and reduced-price meals for schools and school districts. The ACS eligibility estimates would be used to develop "claiming percentages" that, if sufficiently accurate, would determine the USDA reimbursements to districts for schools that provided free meals to all students under a new special provision that eliminated the ongoing base-year requirements of current provisions.

Using American Community Survey Data to Expand Access to the School Meals Program was conducted in two phases. It first issued an interim report (National Research Council, 2010), describing its planned approach for assessing the utility of ACS-based estimates for a special provision to expand access to free school meals. This report is the final phase which presents the panel's findings and recommendations.

The Use and Storage of Methyl Isocyanate (MIC) at Bayer CropScience

Tue, 15 May 2012 17:00:01 EST

The use of hazardous chemicals such as methyl isocyanate can be a significant concern to the residents of communities adjacent to chemical facilities, but is often an integral necessary part of the chemical manufacturing process. In order to ensure that chemical manufacturing takes place in a manner that is safe for workers, members of the local community, and the environment, the philosophy of inherently safer processing can be used to identify opportunities to eliminate or reduce the hazards associated with chemical processing. However, the concepts of inherently safer process analysis have not yet been adopted in all chemical manufacturing plants. The Use and Storage of Methyl Isocyanate (MIC) at Bayer CropScience presents a possible framework to help plant managers choose between alternative processing options-considering factors such as environmental impact and product yield as well as safety- to develop a chemical manufacturing system.

In 2008, an explosion at the Bayer CropScience chemical production plant in Institute, West Virginia, resulted in the deaths of two employees, a fire within the production unit, and extensive damage to nearby structures. The accident drew renewed attention to the fact that the Bayer facility manufactured and stores methyl isocyanate, or MIC - a volatile, highly toxic chemical used in the production of carbonate pesticides and the agent responsible for thousands of death in Bhopal, India, in 1984. In the Institute accident, debris from the blast hit the shield surrounding a MIC storage tank, and although the container was not damaged, an investigation by the U.S. Chemical Safety and Hazard Investigation Board found that the debris could have struck a relief valve vent pipe and cause the release of MIC to the atmosphere.

The Board's investigation also highlighted a number of weaknesses in the Bayer facility's emergency response systems. In light of these concerns, the Board requested the National Research Council convene a committee of independent experts to write a report that examines the use and storage of MIC at the Bayer facility. The Use and Storage of Methyl Isocyanate (MIC) at Bayer CropScience also evaluates the analyses on alternative production methods for MIC and carbamate pesticides preformed by Bayer and the previous owners of the facility.

Urban Meteorology: Forecasting, Monitoring, and Meeting Users' Needs

Tue, 15 May 2012 17:00:01 EST

According to the United Nations, three out of five people will be living in cities worldwide by the year 2030. The United States continues to experience urbanization with its vast urban corridors on the east and west coasts. Although urban weather is driven by large synoptic and meso-scale features, weather events unique to the urban environment arise from the characteristics of the typical urban setting, such as large areas covered by buildings of a variety of heights; paved streets and parking areas; means to supply electricity, natural gas, water, and raw materials; and generation of waste heat and materials.

Urban Meteorology: Forecasting, Monitoring, and Meeting Users' Needs is based largely on the information provided at a Board on Atmospheric Sciences and Climate community workshop. This book describes the needs for end user communities, focusing in particular on needs that are not being met by current urban-level forecasting and monitoring. Urban Meteorology also describes current and emerging meteorological forecasting and monitoring capabilities that have had and will likely have the most impact on urban areas, some of which are not being utilized by the relevant end user communities.

Urban Meteorology explains that users of urban meteorological information need high-quality information available in a wide variety of formats that foster its use and within time constraints set by users' decision processes. By advancing the science and technology related to urban meteorology with input from key end user communities, urban meteorologists can better meet the needs of diverse end users. To continue the advancement within the field of urban meteorology, there are both short-term needs-which might be addressed with small investments but promise large, quick returns-as well as future challenges that could require significant efforts and investments.

Assuring a Future U.S.-Based Nuclear and Radiochemistry Expertise

Tue, 15 May 2012 17:00:01 EST

The growing use of nuclear medicine, the potential expansion of nuclear power generation, and the urgent needs to protect the nation against external nuclear threats, to maintain our nuclear weapons stockpile, and to manage the nuclear wastes generated in past decades, require a substantial, highly trained, and exceptionally talented workforce. Assuring a Future U.S.-Based Nuclear and Radiochemistry Expertise examines supply and demand for expertise in nuclear chemistry nuclear science, and radiochemistry in the United States and presents possible approaches for ensuring adequate availability of these skills, including necessary science and technology training platforms.

Considering a range of reasonable scenarios looking to the future, none of these areas are likely to experience a decrease in demand for expertise. However, many in the current workforce are approaching retirement age and the number of students opting for careers in nuclear and radiochemistry has decreased dramatically over the past few decades. In order to avoid a gap in these critical areas, increases in student interest in these careers, in the research and educational capacity of universities and colleges, and sector specific on-the-job training will be needed. Concise recommendations are given for actions to avoid a shortage of nuclear chemistry, nuclear scientists, and radiochemists in the future.

Alliances for Obesity Prevention: Finding Common Ground: Workshop Summary

Fri, 11 May 2012 17:00:01 EST

Many organizations are making focused efforts to prevent obesity. To achieve their goals, accelerate their progress, and sustain their success, the assistance of many other individuals and groups-not all of them with a singular focus on obesity prevention-will be essential. In October 2011 the Institute of Medicine held a workshop that provided an opportunity for obesity prevention groups to hear from and hold discussions with many of these potential allies in obesity prevention. They explored common ground for joint activities and mutual successes, and lessons learned from efforts at aligning diverse groups with goals in common.

Ranking Vaccines: A Prioritization Framework: Phase I: Demonstration of Concept and a Software Blueprint

Thu, 10 May 2012 17:00:02 EST

As a number of diseases emerge or reemerge thus stimulating new vaccine development opportunities to help prevent those diseases, it can be especially difficult for decision makers to know where to invest their limited resources. Therefore, it is increasingly important for decision makers to have the tools that can assist and inform their vaccine prioritization efforts.

In this first phase report, the IOM offers a framework and proof of concept to account for various factors influencing vaccine prioritization-demographic, economic, health, scientific, business, programmatic, social, policy factors and public concerns. Ranking Vaccines: A Prioritization Framework describes a decision-support model and the blueprint of a software-called Strategic Multi-Attribute Ranking Tool for Vaccines or SMART Vaccines. SMART Vaccines should be of help to decision makers. SMART Vaccines Beta is not available for public use, but SMART Vaccines 1.0 is expected to be released at the end of the second phase of this study, when it will be fully operational and capable of guiding discussions about prioritizing the development and introduction of new vaccines.

A Research Strategy for Environmental, Health, and Safety Aspects of Engineered Nanomaterials

Wed, 09 May 2012 17:00:01 EST

The nanotechnology sector, which generated about $225 billion in product sales in 2009, is predicted to expand rapidly over the next decade with the development of new technologies that have new capabilities. The increasing production and use of engineered nanomaterials (ENMs) may lead to greater exposures of workers, consumers, and the environment, and the unique scale-specific and novel properties of the materials raise questions about their potential effects on human health and the environment. Over the last decade, government agencies, academic institutions, industry, and others have conducted many assessments of the environmental, health, and safety (EHS) aspects of nanotechnology. The results of those efforts have helped to direct research on the EHS aspects of ENMs. However, despite the progress in assessing research needs and despite the research that has been funded and conducted, developers, regulators, and consumers of nanotechnology-enabled products remain uncertain about the types and quantities of nanomaterials in commerce or in development, their possible applications, and their associated risks.

A Research Strategy for Environmental, Health, and Safety Aspects of Engineered Nanomaterials presents a strategic approach for developing the science and research infrastructure needed to address uncertainties regarding the potential EHS risks of ENMs. The report summarizes the current state of the science and high-priority data gaps on the potential EHS risks posed by ENMs and describes the fundamental tools and approaches needed to pursue an EHS risk research strategy. The report also presents a proposed research agenda, short-term and long-term research priorities, and estimates of needed resources and concludes by focusing on implementation of the research strategy and evaluation of its progress, elements that the committee considered integral to its charge.

Community Colleges in the Evolving STEM Education Landscape: Summary of a Summit

Tue, 08 May 2012 17:00:01 EST

The National Research Council (NRC) has released a new report, Community Colleges in the Evolving STEM Education Landscape: Summary of a Summit. Based on a national summit that was supported by the National Science Foundation and organized by the National Research Council and the National Academy of Engineering, the report highlights the importance of community colleges, especially in emerging areas of STEM and preparation of the STEM workforce.

Community colleges also are essential in accommodating growing numbers of students and in retraining displaced workers in skills needed in the new economy. The report looks at the changing and evolving relationships between community colleges and four-year institutions, with a focus on partnerships and articulation processes that can facilitate student success in STEM; expanding participation of students from historically underrepresented populations in undergraduate STEM education; and how subjects, such as mathematics, can serve as gateways or barriers to college completion.

Accelerating Progress in Obesity Prevention: Solving the Weight of the Nation

Tue, 08 May 2012 17:00:01 EST

Two-thirds of adults and one-third of children are overweight or obese. Left unchecked, obesity's effects on health, health care costs, and our productivity as a nation could become catastrophic. The staggering human toll of obesity-related chronic disease and disability and an annual cost of $190.2 billion for treating obesity-related illness underscore the urgent need to strengthen obesity prevention efforts in the United States. The IOM evaluated prior obesity-prevention strategies and identified recommendations to accelerate progress. The IOM's recommendations, when implemented together, could profoundly reshape the environments where people live, learn, work, and play.

NASA Space Technology Roadmaps and Priorities: Restoring NASA's Technological Edge and Paving the Way for a New Era in Space

Mon, 07 May 2012 17:00:01 EST

NASA's Office of the Chief Technologist (OCT) has begun to rebuild the advanced space technology program in the agency with plans laid out in 14 draft technology roadmaps. It has been years since NASA has had a vigorous, broad-based program in advanced space technology development and its technology base has been largely depleted. However, success in executing future NASA space missions will depend on advanced technology developments that should already be underway. Reaching out to involve the external technical community, the National Research Council (NRC) considered the 14 draft technology roadmaps prepared by OCT and ranked the top technical challenges and highest priority technologies that NASA should emphasize in the next 5 years. This report provides specific guidance and recommendations on how the effectiveness of the technology development program managed by OCT can be enhanced in the face of scarce resources.

Earth Science and Applications from Space: A Midterm Assessment of NASA's Implementation of the Decadal Survey

Thu, 03 May 2012 17:00:02 EST

Natural and human-induced changes in Earth's interior, land surface, biosphere, atmosphere, and oceans affect all aspects of life. Understanding these changes and their implications requires a foundation of integrated observations of land, sea, air and space, on which to build credible information products, forecast models, and other tools for making informed decisions.

The 2007 National Research Council report on decadal survey called for a renewal of the national commitment to a program of Earth observations in which attention to securing practical benefits for humankind plays an equal role with the quest to acquire new knowledge about the Earth system. NASA responded favorably and aggressively to this survey, embracing its overall recommendations for Earth observations, missions, technology investments, and priorities for the underlying science. As a consequence, the science and applications communities have made significant progress over the past 5 years. Earth Science and Applications from Space: A Midterm Assessment of NASA's Implementation of the Decadal Survey assesses the following:

1. How well NASA's current program addresses the strategies, goals, and priorities outline in the 2007 decadal survey and other relevant NRC reports;
2. Progress toward realizing these strategies, goals, and priorities; and
3. In the context of current and forecast resources, any actions that could be taken to optimize the science value of the program.

Earth Science and Applications from Space: A Midterm Assessment of NASA's Implementation of the Decadal Survey also provides guidance about implementing the recommended mission portfolio in preparation for the next decadal survey.

Aging in Asia: Findings from New and Emerging Data Initiatives

Thu, 03 May 2012 17:00:02 EST

The population of Asia is growing both larger and older. Demographically the most important continent on the world, Asia's population, currently estimated (by the Population Division of the United States) to be 4.2 billion, is expected to increase to about 5.9 billion by 2050. Rapid declines in fertility, together with rising life expectancy, are altering the age structure of the population so that in 2050, for the first time in history, there will be roughly as many people in Asia over the age of 65 as under the age of 15.

It is against this backdrop that the Division of Behavioral and Social Research at the U.S. National Institute on Aging (NIA) asked the National Research Council (NRC), through the Committee on Population, to undertake a project on advancing research on behavioral and social aging in Asia. Aging in Asia: Findings from New and Emerging Data Initiatives explains the findings from both parts of this project. The first of the project's two activities was a collaborative effort with the Chinese Academy of Social Sciences, the Indian National Science Academy, the Indonesian Academy of Sciences, and the Science Council of Japan to develop a report on strengthening the scientific basis for developing policies to meet the challenges of population aging in Asia.

Aging in Asia: Findings from New and Emerging Data Initiatives also covers the second part of the project, which included two conferences in Beijing, hosted by the Chinese Academy of Social Sciences, on December 9-10, 2010 and the second in New Delhi, hosted by the Indian National Science Academy, on March 14-15, 2011. This report summarizes these conferences, which provided an opportunity for Asian and other researchers to discuss important data collection initiatives taking place throughout the region, exchange knowledge, share common experiences, and engage with policy makers.

Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 12

Tue, 01 May 2012 17:00:01 EST

Extremely hazardous substances (EHSs) can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists.

Using the 1993 and 2001 NRC guidelines reports, the National Advisory Committee - consisting of members from the Environmental Protection Agency, the Department of Defense, the Department of Energy, the Department of Transportation, other federal and state governments, the chemical industry, academia, and other organizations form the private sector has developed Acute Exposure Guideline Levels (AEGL) for more than 270 EHSs.

In 1998, the EPA and DOD requested that the NRC independently reviewed the AEGLs developed by the NAC. In response to that request, the NRC organized within its Committee on Toxicology the Committee on Acute Exposure Guideline Levels, which prepared this report, Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 12. This report explains the scientifically valid conclusions that are based on the data reviewed by NAC and consistent with the NRC guideline reports and provides comments and recommendations for how AEGL could be improved.

Living Well with Chronic Illness: A Call for Public Health Action

Tue, 01 May 2012 17:00:01 EST

In the United States, chronic diseases currently account for 70 percent of all deaths, and close to 48 million Americans report a disability related to a chronic condition. Today, about one in four Americans have multiple diseases and the prevalence and burden of chronic disease in the elderly and racial/ethnic minorities are notably disproportionate. Chronic disease has now emerged as a major public health problem and it threatens not only population health, but our social and economic welfare.

Living Well with Chronic Disease identifies the population-based public health actions that can help reduce disability and improve functioning and quality of life among individuals who are at risk of developing a chronic disease and those with one or more diseases. The book recommends that all major federally funded programmatic and research initiatives in health include an evaluation on health-related quality of life and functional status. Also, the book recommends increasing support for implementation research on how to disseminate effective longterm lifestyle interventions in community-based settings that improve living well with chronic disease.

Living Well with Chronic Disease uses three frameworks and considers diseases such as heart disease and stroke, diabetes, depression, and respiratory problems. The book's recommendations will inform policy makers concerned with health reform in public- and private-sectors and also managers of communitybased and public-health intervention programs, private and public research funders, and patients living with one or more chronic conditions.

Ethical and Scientific Issues in Studying the Safety of Approved Drugs

Tue, 01 May 2012 17:00:01 EST

An estimated 48 percent of the population takes at least one prescription drug in a given month. Drugs provide great benefits to society by saving or improving lives. Many drugs are also associated with side effects or adverse events, some serious and some discovered only after the drug is on the market. The discovery of new adverse events in the postmarketing setting is part of the normal natural history of approved drugs, and timely identification and warning about drug risks are central to the mission of the Food and Drug Administration (FDA). Not all risks associated with a drug are known at the time of approval, because safety data are collected from studies that involve a relatively small number of human subjects during a relatively short period.

Written in response to a request by the FDA, Ethical and Scientific Issues in Studying the Safety of Approved Drugs discusses ethical and informed consent issues in conducting studies in the postmarketing setting. It evaluates the strengths and weaknesses of various approaches to generate evidence about safety questions, and makes recommendations for appropriate followup studies and randomized clinical trials. The book provides guidance to the FDA on how it should factor in different kinds of evidence in its regulatory decisions.

Ethical and Scientific Issues in Studying the Safety of Approved Drugs will be of interest to the pharmaceutical industry, patient advocates, researchers, and consumer groups.

Deterrence and the Death Penalty

Fri, 27 Apr 2012 17:00:01 EST

Many studies during the past few decades have sought to determine whether the death penalty has any deterrent effect on homicide rates. Researchers have reached widely varying, even contradictory, conclusions. Some studies have concluded that the threat of capital punishment deters murders, saving large numbers of lives; other studies have concluded that executions actually increase homicides; still others, that executions have no effect on murder rates. Commentary among researchers, advocates, and policymakers on the scientific validity of the findings has sometimes been acrimonious.

Against this backdrop, the National Research Council report Deterrence and the Death Penalty assesses whether the available evidence provides a scientific basis for answering questions of if and how the death penalty affects homicide rates. This new report from the Committee on Law and Justice concludes that research to date on the effect of capital punishment on homicide rates is not useful in determining whether the death penalty increases, decreases, or has no effect on these rates. The key question is whether capital punishment is less or more effective as a deterrent than alternative punishments, such as a life sentence without the possibility of parole. Yet none of the research that has been done accounted for the possible effect of noncapital punishments on homicide rates. The report recommends new avenues of research that may provide broader insight into any deterrent effects from both capital and noncapital punishments.

Research in the Life Sciences with Dual Use Potential: An International Faculty Development Project on Education About the Responsible Conduct of Science

Fri, 27 Apr 2012 17:00:01 EST

In many countries, colleges and universities are where the majority of innovative research is done; in all cases, they are where future scientists receive both their initial training and their initial introduction to the norms of scientific conduct regardless of their eventual career paths. Thus, institutions of higher education are particularly relevant to the tasks of education on research with dual use potential, whether for faculty, postdoctoral researchers, graduate and undergraduate students, or technical staff.

Research in the Life Sciences with Dual Use Potential describes the outcomes of the planning meeting for a two-year project to develop a network of faculty who will be able to teach the challenges of research in the life sciences with dual use potential. Faculty will be able to incorporate such concepts into their teaching and research through exposure to the tenets of responsible conduct of research in active learning teaching methods. This report is intended to provide guidelines for that effort and to be applicable to any country wishing to adopt this educational model that combines principles of active learning and training with attention to norms of responsible science. The potential audiences include a broad array of current and future scientists and the policymakers who develop laws and regulations around issues of dual use.

Facing the Reality of Drug-Resistant Tuberculosis: Challenges and Potential Solutions in India: Summary of a Joint Workshop by the Institute of Medicine, the Indian National Science Academy, and the Indian Council of Medical Research

Fri, 27 Apr 2012 17:00:01 EST

An estimated 8.8 million people fell ill with tuberculosis (TB) in 2010 and 1.4 million died from the disease. Although antibiotics to treat TB were developed in the 1950s and are effective against a majority of TB cases, resistance to these antibiotics has emerged over the years, resulting in the growing spread of multidrug-resistant (MDR) TB. Due to challenges in timely and accurate diagnosis of drug-resistant TB, length and tolerability of treatment regimens, and expense of second-line anti-TB drugs, effectively controlling the disease requires complex public health interventions.

The IOM Forum on Drug Discovery, Development, and Translation held three international workshops to gather information from local experts around the world on the threat of drug resistant TB and how the challenges it presents can be met. Workshops were held in South Africa [LINK] and Russia [LINK] in 2010. The third workshop was held April 18-19, 2011, in New Delhi, India, in collaboration with the Indian National Science Academy and the Indian Council of Medical Research. The aim of the workshop was to highlight key challenges to controlling the spread of drug-resistant strains of TB in India and to discuss strategies for advancing and integrating local and international efforts to prevent and treat drug-resistant TB. This document summarizes the workshop.

Thinking Evolutionarily: Evolution Education Across the Life Sciences: Summary of a Convocation

Thu, 26 Apr 2012 17:00:01 EST

Evolution is the central unifying theme of biology. Yet today, more than a century and a half after Charles Darwin proposed the idea of evolution through natural selection, the topic is often relegated to a handful of chapters in textbooks and a few class sessions in introductory biology courses, if covered at all. In recent years, a movement has been gaining momentum that is aimed at radically changing this situation.

On October 25-26, 2011, the Board on Life Sciences of the National Research Council and the National Academy of Sciences held a national convocation in Washington, DC, to explore the many issues associated with teaching evolution across the curriculum. Thinking Evolutionarily: Evolution Education Across the Life Sciences: Summary of a Convocation summarizes the goals, presentations, and discussions of the convocation. The goals were to articulate issues, showcase resources that are currently available or under development, and begin to develop a strategic plan for engaging all of the sectors represented at the convocation in future work to make evolution a central focus of all courses in the life sciences, and especially into introductory biology courses at the college and high school levels, though participants also discussed learning in earlier grades and life-long learning.

Thinking Evolutionarily: Evolution Education Across the Life Sciences: Summary of a Convocation covers the broader issues associated with learning about the nature, processes, and limits of science, since understanding evolutionary science requires a more general appreciation of how science works. This report explains the major themes that recurred throughout the convocation, including the structure and content of curricula, the processes of teaching and learning about evolution, the tensions that can arise in the classroom, and the target audiences for evolution education.

Geographic Adjustment in Medicare Payment: Phase I: Improving Accuracy, Second Edition

Wed, 25 Apr 2012 17:00:01 EST

Medicare is the largest health insurer in the United States, providing coverage for 39 million people aged 65 and older and 8 million people with disabilities, and reaching more than an estimated $500 billion in payments in 2010. Although Medicare is a national program, it adjusts fee-for-service payments according to the geographic location of a practice. While there is widespread agreement about the importance of providing accurate payments to providers, there is disagreement about how best to adjust payment based on geographic location.

At the request of Congress and the Department of Health and Human Services (HHS), the Institute of Medicine (IOM) examined ways to improve the accuracy of data sources and methods used for making the geographic adjustments to payments. The IOM recommends an integrated approach that includes moving to a single source of wage and benefits data; changing to one set of payment areas; and expanding the range of occupations included in the index calculations. The first of two reports, Geographic Adjustment in Medicare Payment: Phase I: Improving Accuracy, assesses existing practices in regards to accuracy, criteria consistency, evidence for adjustment, sound rationale, transparency, and separate policy adjustments to reform the current payment system. Adopting the recommendations outlined in this report will mean a change in the way that the indexes are calculated, and will require a combination of legislative, rule-making, and administrative actions, as well as a period of public comment.

Geographic Adjustment in Medicare Payment will inform the work of government agencies such as HHS, the Centers for Medicare and Medicaid Services, congressional members and staff, the health care industry, national professional organizations and state medical and nursing societies, and Medicare advocacy groups.

Ecosystem Services: Charting a Path to Sustainability

Mon, 23 Apr 2012 17:00:02 EST

Natural environments provide enormously valuable, but largely unappreciated, services that aid humans and other earthlings. It is becoming clear that these life-support systems are faltering and failing worldwide due to human actions that disrupt nature's ability to do its beneficial work.

Ecosystem Services: Charting a Path to Sustainability documents the National Academies' Keck Futures Initiative Conference on Ecosystem Services. At this conference, participants were divided into 14 interdisciplinary research teams to explore diverse challenges at the interface of science, engineering, and medicine. The teams needed to address the challenge of communicating and working together from a diversity of expertise and perspectives as they attempted to solve a complicated, interdisciplinary problem in a relatively short time. Ecosystem Services: Charting a Path to Sustainability describes how ecosystem services scientists work to document the direct and indirect links between humanity's well-being and the many benefits provided by the natural systems we occupy.

This report explains the specific topics the interdisciplinary research teams addressed at the conference, including the following:

-how ecosystem services affect infectious and chronic diseases
-how to identify what resources can be produced renewably or recovered by developing intense technologies that can be applied on a massive scale
-how to develop social and technical capabilities to respond to abrupt changes in ecosystem services
-how to design agricultural and aquacultural systems that provide food security while maintaining the full set of ecosystem services needed from landscapes and seascapes
-how to design production systems for ecosystem services that improve human outcomes related to food and nutrition
-how to develop appropriate methods to accurately value natural capital and ecosystem services
-how to design a federal policy to maintain or improve natural capital and ecosystem services within the United States, including measuring and documenting the effectiveness of the policy
-how to design a system for international trade that accounts for impacts on ecosystem services
-how to develop a program that increases the American public's appreciation of the basic principles of ecosystem services

Assessment of Planetary Protection Requirements for Spacecraft Missions to Icy Solar System Bodies

Wed, 18 Apr 2012 17:00:01 EST

NASA's exploration of planets and satellites over the past 50 years has led to the discovery of traces of water ice throughout the solar system and prospects for large liquid water reservoirs beneath the frozen ICE shells of multiple satellites of the giant planets of the outer solar system. During the coming decades, NASA and other space agencies will send flybys, orbiters, subsurface probes, and, possibly, landers to these distant worlds in order to explore their geologic and chemical context. Because of their potential to harbor alien life, NASA will select missions that target the most habitable outer solar system objects. This strategy poses formidable challenges for mission planners who must balance the opportunity for exploration with the risk of contamination by Earth's microbes, which could confuse the interpretation of data obtained from these objects. The 2000 NRC report Preventing the Forward Contamination of Europa provided a criterion that was adopted with prior recommendations from the Committee on Space Research of the International Council for Science. This current NRC report revisits and extends the findings and recommendations of the 2000 Europa report in light of recent advances in planetary and life sciences and, among other tasks, assesses the risk of contamination of icy bodies in the solar system.

Envisioning a Transformed Clinical Trials Enterprise in the United States: Establishing an Agenda for 2020: Workshop Summary

Fri, 13 Apr 2012 17:00:01 EST

There is growing recognition that the United States' clinical trials enterprise (CTE) faces great challenges. There is a gap between what is desired - where medical care is provided solely based on high quality evidence - and the reality - where there is limited capacity to generate timely and practical evidence for drug development and to support medical treatment decisions.

With the need for transforming the CTE in the U.S. becoming more pressing, the IOM Forum on Drug Discovery, Development, and Translation held a two-day workshop in November 2011, bringing together leaders in research and health care. The workshop focused on how to transform the CTE and discussed a vision to make the enterprise more efficient, effective, and fully integrated into the health care system. Key issue areas addressed at the workshop included: the development of a robust clinical trials workforce, the alignment of cultural and financial incentives for clinical trials, and the creation of a sustainable infrastructure to support a transformed CTE. This document summarizes the workshop.

Barriers to Integrating Crisis Standards of Care Principles into International Disaster Response Plans: Workshop Summary

Tue, 10 Apr 2012 17:00:02 EST

When a nation or region prepares for public health emergencies such as a pandemic influenza, a large-scale earthquake, or any major disaster scenario in which the health system may be destroyed or stressed to its limits, it is important to describe how standards of care would change due to shortages of critical resources. At the 17th World Congress on Disaster and Emergency Medicine, the IOM Forum on Medical and Public Health Preparedness sponsored a session that focused on the promise of and challenges to integrating crisis standards of care principles into international disaster response plans.

For the Public's Health: Investing in a Healthier Future

Tue, 10 Apr 2012 17:00:02 EST

The Robert Wood Johnson Foundation asked the Institute of Medicine (IOM) to examine three topics in relation to public health: measurement, the law, and funding. IOM prepared a three report series-one report on each topic-that contains actionable recommendations for public health agencies and other stakeholders with roles in the health of the U.S. population.

For the Public's Health: The Report on Funding, the final book inthe series, assesses the financial challenges facing the governmental public health infrastructure. The book provides recommendations about what is needed for stable and sustainable funding, and for its optimal use by public health agencies.

Building on the other two volumes in the series, this book makes the argument that adequate and sustainable funding for public health is necessary to enable public health departments across the country to inform and mobilize action on the determinants of health, to play other key roles in protecting and promoting health, and to prepare for a range of potential threats to population health.

The final book in the For the Public's Health series will be useful to federal, state, and local governments; public health agencies; clinical care organizations; and community-based organizations.

Building a Resilient Workforce: Opportunities for the Department of Homeland Security: Workshop Summary

Mon, 09 Apr 2012 17:00:02 EST

Every job can lead to stress for a variety of reasons. How a person responds to stress in the workplace can be determined by the workplace environment. The Department of Homeland Security (DHS) has raised concerns that long-term exposures to stressors may reduce individual resilience and negatively affect employee's physical and mental well-being. DHS employs a diverse staff that includes emergency responders, border patrol agents, federal air marshals, and policy analysts. These employees may be exposed to traumatic and disturbing information as part of their jobs. Additionally, many positions within DHS require employees to have a security clearance, which can make it difficult to seek assistance.

To explore DHS workforce resiliency, the Institute of Medicine hosted two workshops in September and November 2011. The September workshop focused on DHS's operational and law enforcement personnel, while the November workshop concentrated on DHS policy and program personnel with top secret security clearances. The workshop brought together an array of experts from various fields including resiliency research, occupation health psychology, and emergency response. This document summarizes the workshops.

Child Maltreatment Research, Policy, and Practice for the Next Decade: Workshop Summary

Fri, 06 Apr 2012 17:00:01 EST

In 1993 the National Research Council released its landmark report Understanding Child Abuse and Neglect (NRC, 1993). That report identified child maltreatment as a devastating social problem in American society. Nearly 20 years later, on January 30-31, 2012, the Institute of Medicine (IOM) and NRC's Board on Children, Youth and Families help a workshop, Child Maltreatment Research, Policy, and Practice for the Next Generation, to review the accomplishments of the past two decades of research related to child maltreatment and the remaining gaps. "There have been many exciting research discoveries since the '93 report, but we also want people to be thinking about what is missing," said Anne Petersen, research professor at the Center for Human Growth and Development at the University of Michigan and chair of the panel that produced the report.

Child Maltreatment Research, Policy, and Practice for the Next Decade: Workshop Summary covers the workshop that brought together many leading U.S. child maltreatment researchers for a day and a half of presentations and discussions. Presenters reviewed research accomplishments, identified gaps that remain in knowledge, and consider potential research priorities. Child Maltreatment Research, Policy, and Practice for the Next Decade: Workshop Summary also covers participant suggestions for future research priorities, policy actions, and practices that would enhance understanding of child maltreatment and efforts to reduce and respond to it. A background paper highlighting major research advances since the publication of the 1993 NRC report was prepared by an independent consultant to inform the workshop discussions.

This summary is an essential resource for any workshop attendees, policy makers, researchers, educators, healthcare providers, parents, and advocacy groups.

The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary

Fri, 06 Apr 2012 17:00:01 EST

Recent research suggests that obesity and excess weight can play a prominent role in the incidence and progression of various cancers. Obesity results from an energy imbalance - that is, energy intake that is higher than energy expenditure - could also influence the growth of cancers. Recognizing the impact that current findings on obesity and cancer could have on future cancer prevention and care, the National Cancer policy Forum (NCPF) of the Institute of Medicine (IOM) help a 2-day workshop on "The Role of Obesity in Cancer Survival and Recurrence," in Washington, DC, on October 31 and November 1, 2011.

The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary reviews each presenter's latest clinical evidence on the obesity-cancer link and the molecular mechanisms that might explain that link. Clinicians, researchers, cancer survivors, and policy makers also discussed potential interventions to counter the effects of obesity on cancer, and research and policy measures needed to stem the rising tide of cancer mortality predicted by an increasingly overweight and older population worldwide.

The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary explores the complex web of molecular mechanisms that underlie the obesity-cancer link, the ways to design future studies to acquire the information needed to guide patient care, what to advise cancer patients about weight loss, diet, exercise, and other measures to reduce their risk of cancer progression or recurrence and policy suggestions related to research, education, and dissemination of the findings on obesity and cancer.

Space Studies Board Annual Report 2011

Fri, 06 Apr 2012 17:00:01 EST

The original charter of the Space Science Board was established in June 1958, 3 months before the National Aeronautics and Space Administration (NASA) opened its doors. The Space Science Board and its successor, the Space Studies Board (SSB), have provided expert external and independent scientific and programmatic advice to NASA on a continuous basis from NASA's inception until the present. The SSB has also provided such advice to other executive branch agencies, including the National Oceanic and Atmospheric Administration (NOAA), the National Science Foundation (NSF), the U.S. Geological Survey (USGS), the Department of Defense, as well as to Congress.

Space Studies Board Annual Report 2011 covers a message from the chair of the SSB, Charles F. Kennel, where he expresses that 2011 was a challenging and uncertain year for NASA and the space science research communities. This report also explains the origins of the Space Science Board, how the Space Studies Board functions today, the SSB's collaboration with other National Research Council units, assures the quality of the SSB reports, acknowledges the audience and sponsors, and expresses the necessity to enhance the outreach and improve dissemination of SSB reports.

This report will be relevant to a full range of government audiences in civilian space research - including NASA, NSF, NOAA, USGS, and the Department of Energy, as well members of the SSB, policy makers, and researchers.

Ensuring Safe Foods and Medical Products Through Stronger Regulatory Systems Abroad

Fri, 06 Apr 2012 17:00:01 EST

A very high portion of the seafood we eat comes from abroad, mainly from China and Southeast Asia and most of the active ingredients in medicines we take originate in other countries. Many low and middle income countries have lower labor costs and fewer and less stringent environmental regulations than the United States, making them attractive places to produce food and chemical ingredients for export. Safe Foods and Medical Products Through Stronger Regulatory Systems Abroad explains that the diversity and scale of imports makes it impractical for U.S. Food and Drug Administration (FDA) border inspections to be sufficient to ensure product purity and safety, and incidents such as American deaths due to adulterated heparin imported from China propelled the problem into public awareness.

The Institute of Medicine Committee on Strengthening Core Elements of Regulatory Systems in Developing Countries took up the vital task of helping the FDA to cope with the reality that so much of the food, drugs, biologics, and medical products consumed in the United States originate in countries with less-robust regulatory systems. Ensuring Safe Foods and Medical Products Through Stronger Regulatory Systems Abroad describes the ways the United States can help strengthen regulatory systems in low and middle income countries and promote cross-border partnerships - including government, industry, and academia - to foster regulatory science and build a core of regulatory professionals. This report also emphasizes an array of practical approaches to ensure sound regulatory practices in today's interconnected world.

Strengthening a Workforce for Innovative Regulatory Science in Therapeutics Development: Workshop Summary

Wed, 04 Apr 2012 17:00:01 EST

The development and application of regulatory science - which FDA has defined as the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products - calls for a well-trained, scientifically engaged, and motivated workforce. FDA faces challenges in retaining regulatory scientists and providing them with opportunities for professional development. In the private sector, advancement of innovative regulatory science in drug development has not always been clearly defined, well coordinated, or connected to the needs of the agency. As a follow-up to a 2010 workshop, the IOM held a workshop on September 20-21, 2011, to provide a format for establishing a specific agenda to implement the vision and principles relating to a regulatory science workforce and disciplinary infrastructure as discussed in the 2010 workshop.

Lessons and Legacies of the International Polar Year 2007-2008

Tue, 03 Apr 2012 17:00:01 EST

International Polar Year 2007-2008 (IPY) was an intense, coordinated field campaign of observations, research, and analysis. IPY engaged the public to communicate the relevance of polar research to the entire planet, strengthened connections with the Indigenous people of the Arctic, and established new observational networks. Overall, IPY was an outstanding success. Activities at both poles led to scientific discoveries that provided a step change in scientific understanding and helped translate scientific knowledge into policy-relevant information-and at a time when the polar regions are undergoing a transformation from an icy wilderness to a new zone for human affairs, these insights could not be more timely or more relevant. From outreach activities that engaged the general public to projects that brought researchers from multiple disciplines and several nations together, the legacies of IPY extend far beyond the scientific results achieved, and valuable lessons learned from the process will guide future endeavors of similar magnitude.

Assessing the Reliability of Complex Models: Mathematical and Statistical Foundations of Verification, Validation, and Uncertainty Quantification

Mon, 02 Apr 2012 17:00:01 EST

Advances in computing hardware and algorithms have dramatically improved the ability to simulate complex processes computationally. Today's simulation capabilities offer the prospect of addressing questions that in the past could be addressed only by resource-intensive experimentation, if at all. Assessing the Reliability of Complex Models recognizes the ubiquity of uncertainty in computational estimates of reality and the necessity for its quantification.

As computational science and engineering have matured, the process of quantifying or bounding uncertainties in a computational estimate of a physical quality of interest has evolved into a small set of interdependent tasks: verification, validation, and uncertainty of quantification (VVUQ). In recognition of the increasing importance of computational simulation and the increasing need to assess uncertainties in computational results, the National Research Council was asked to study the mathematical foundations of VVUQ and to recommend steps that will ultimately lead to improved processes.

Assessing the Reliability of Complex Models discusses changes in education of professionals and dissemination of information that should enhance the ability of future VVUQ practitioners to improve and properly apply VVUQ methodologies to difficult problems, enhance the ability of VVUQ customers to understand VVUQ results and use them to make informed decisions, and enhance the ability of all VVUQ stakeholders to communicate with each other. This report is an essential resource for all decision and policy makers in the field, students, stakeholders, UQ experts, and VVUQ educators and practitioners.

Analysis of Cancer Risks in Populations Near Nuclear Facilities: Phase I

Mon, 02 Apr 2012 17:00:01 EST

In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity.

Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.

Primary Care and Public Health: Exploring Integration to Improve Population Health

Mon, 02 Apr 2012 17:00:01 EST

Ensuring that members of society are healthy and reaching their full potential requires the prevention of disease and injury; the promotion of health and well-being; the assurance of conditions in which people can be healthy; and the provision of timely, effective, and coordinated health care. Achieving substantial and lasting improvements in population health will require a concerted effort from all these entities, aligned with a common goal. The Health Resources and Services Administration (HRSA) and the Centers for Disease Control and Prevention (CDC) requested that the Institute of Medicine (IOM) examine the integration of primary care and public health.

Primary Care and Public Health identifies the best examples of effective public health and primary care integration and the factors that promote and sustain these efforts, examines ways by which HRSA and CDC can use provisions of the Patient Protection and Affordable Care Act to promote the integration of primary care and public health, and discusses how HRSA-supported primary care systems and state and local public health departments can effectively integrate and coordinate to improve efforts directed at disease prevention.

This report is essential for all health care centers and providers, state and local policy makers, educators, government agencies, and the public for learning how to integrate and improve population health.

Effective Tracking of Building Energy Use: Improving the Commercial Buildings and Residential Energy Consumption Surveys

Mon, 02 Apr 2012 17:00:01 EST

The United States is responsible for nearly one-fifth of the world's energy consumption. Population growth, and the associated growth in housing, commercial floor space, transportation, goods, and services is expected to cause a 0.7 percent annual increase in energy demand for the foreseeable future. The energy used by the commercial and residential sectors represents approximately 40 percent of the nation's total energy consumption, and the share of these two sectors is expected to increase in the future.

The Commercial Buildings Energy Consumption Survey (CBECS) and Residential Energy Consumption Survey (RECS) are two major surveys conducted by the Energy Information Administration. The surveys are the most relevant sources of data available to researchers and policy makers on energy consumption in the commercial and residential sectors. Many of the design decisions and operational procedures for the CBECS and RECS were developed in the 1970s and 1980s, and resource limitations during much of the time since then have prevented EIA from making significant changes to the data collections. Effective Tracking of Building Energy Use makes recommendations for redesigning the surveys based on a review of evolving data user needs and an assessment of new developments in relevant survey methods.

Country-Level Decision Making for Control of Chronic Diseases: Workshop Summary

Mon, 02 Apr 2012 17:00:02 EST

A 2010 IOM report, Promoting Cardiovascular Health in the Developing World, found that not only is it possible to reduce the burden of cardiovascular disease and related chronic diseases in developing countries, but also that such a reduction will be critical to achieving global health and development goals. As part a series of follow-up activities to the 2010 report, the IOM held a workshop that aimed to identify what is needed to create tools for country-led planning of effective, efficient, and equitable provision of chronic disease control programs.

Challenges in Characterizing Small Particles: Exploring Particles from the Nano- to Microscales

Mon, 02 Apr 2012 17:00:02 EST

Small particles are ubiquitous in the natural and built worlds and have tremendous impact throughout. However, a lack of understanding about the properties and chemical composition of small particles limits our ability to predict, and control their applications and impacts.

Challenges in Characterizing Small Particles: Exploring Particles from the Nano- to Microscales summarizes presentations and discussions at a 2010 National Academies roundtable. Speakers at this roundtable discussed the crucial types of information that need to be determined about small particles in different media. They also explored the critical importance of small particles in environmental science, materials and chemical sciences, biological science, and engineering, and the many challenges involved in characterizing materials at the nano- and microscales. The discussions on characterization included static, dynamic, experimental, computational, and theoretical characterization. The workshop also included several "research tool" presentations that highlighted new advances in characterizing small particles.

Global Navigation Satellite Systems: Report of a Joint Workshop of the National Academy of Engineering and the Chinese Academy of Engineering

Mon, 02 Apr 2012 17:00:02 EST

The Global Positioning System (GPS) has revolutionized the measurement of position, velocity, and time. It has rapidly evolved into a worldwide utility with more than a billion receiver sets currently in use that provide enormous benefits to humanity: improved safety of life, increased productivity, and wide-spread convenience. Global Navigation Satellite Systems summarizes the joint workshop on Global Navigation Satellite Systems held jointly by the U.S. National Academy of Engineering and the Chinese Academy of Engineering on May 24-25, 2011 at Hongqiao Guest Hotel in Shanghai, China.

"We have one world, and only one set of global resources. It is important to work together on satellite navigation. Competing and cooperation is like Yin and Yang. They need to be balanced," stated Dr. Charles M. Vest, President of the National Academy of Engineering, in the workshop's opening remarks. Global Navigation Satellite Systems covers the objectives of the workshop, which explore issues of enhanced interoperability and interchangeability for all civil users aimed to consider collaborative efforts for countering the global threat of inadvertent or illegal interference to GNSS signals, promotes new applications for GNSS, emphasizing productivity, safety, and environmental protection.

The workshop featured presentations chosen based on the following criteria: they must have relevant engineering/technical content or usefulness; be of mutual interest; offer the opportunity for enhancing GNSS availability, accuracy, integrity, and/or continuity; and offer the possibility of recommendations for further actions and discussions. Global Navigation Satellite Systems is an essential report for engineers, workshop attendees, policy makers, educators, and relevant government agencies.

The Comprehensive Nuclear Test Ban Treaty: Technical Issues for the United States

Mon, 02 Apr 2012 17:00:02 EST

This report reviews and updates the 2002 National Research Council report, Technical Issues Related to the Comprehensive Nuclear Test Ban Treaty (CTBT). This report also assesses various topics, including:

the plans to maintain the safety and reliability of the U.S. nuclear stockpile without nuclear-explosion testing;
the U.S. capability to detect, locate, and identify nuclear explosions;
commitments necessary to sustain the stockpile and the U.S. and international monitoring systems; and
potential technical advances countries could achieve through evasive testing and unconstrained testing.

Sustaining these technical capabilities will require action by the National Nuclear Security Administration, with the support of others, on a strong scientific and engineering base maintained through a continuing dynamic of experiments linked with analysis, a vigorous surveillance program, adequate ratio of performance margins to uncertainties. This report also emphasizes the use of modernized production facilities and a competent and capable workforce with a broad base of nuclear security expertise.

Epilepsy Across the Spectrum: Promoting Health and Understanding

Fri, 30 Mar 2012 17:00:01 EST

Although epilepsy is one of the nation's most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should do if they see someone having a seizure. Epilepsy is a complex spectrum of disorders that affects an estimated 2.2 million Americans in a variety of ways, and is characterized by unpredictable seizures that differ in type, cause, and severity. Yet living with epilepsy is about much more than just seizures; the disorder is often defined in practical terms, such as challenges in school, uncertainties about social situations and employment, limitations on driving, and questions about independent living.

The Institute of Medicine was asked to examine the public health dimensions of the epilepsies, focusing on public health surveillance and data collection; population and public health research; health policy, health care, and human services; and education for people with the disorder and their families, health care providers, and the public. In Epilepsy Across the Spectrum, the IOM makes recommendations ranging from the expansion of collaborative epilepsy surveillance efforts, to the coordination of public awareness efforts, to the engagement of people with epilepsy and their families in education, dissemination, and advocacy for improved care and services. Taking action across multiple dimensions will improve the lives of people with epilepsy and their families. The realistic, feasible, and action-oriented recommendations in this report can help enable short- and long-term improvements for people with epilepsy. For all epilepsy organizations and advocates, local, state, and federal agencies, researchers, health care professionals, people with epilepsy, as well as the public, Epilepsy Across the Spectrum is an essential resource.

Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 11

Fri, 30 Mar 2012 17:00:01 EST

At the request of the Department of Defense and the Environmental Protection Agency, the National Research Council has reviewed the relevant scientific literature compiled by an expert panel and established Acute Exposure Guideline Levels (AEGLs) for several chemicals. AEGLs represent exposure levels below which adverse health effects are not likely to occur and are useful in responding to emergencies, such as accidental or intentional chemical releases in community, workplace, transportation, and military settings, and for the remediation of contaminated sites. Three AEGLs are approved for each chemical, representing exposure levels that result in: 1) notable but reversible discomfort; 2) long-lasting health effects; and 3) life-threatening health impacts. This volume in the series includes AEGLs for bis-chloromethyl ether, chloromethyl methyl ether, chlorosilanes, nitrogen oxides, and vinyl chloride.

Sustainable Water and Environmental Management in the California Bay-Delta

Thu, 29 Mar 2012 17:00:01 EST

Water management in the California Bay Delta is directed toward providing a more reliable water supply for California, and protecting and rehabilitating the Delta ecosystem, including five endangered and threatened populations and species of fish that live in or migrate through the Delta. However, water management in the Bay and Delta is distributed among many agencies and organizations, a structure that hinders the development and implementation of an integrated, comprehensive plan. As a result, recent Bay Delta planning efforts have not resolved the best plan for the environment or for satisfying anticipated water needs. Challenges include the fact that water scarcity has not been adequately addressed in planning for Delta water and environmental management; the interacting effects of the many environmental stressors that impact the Delta ecosystem, and the many biological and physical effects of climate change. This report discusses the issue of scarcity, factors affecting the listed species and the Delta ecosystem in general, future water-supply and delivery options, scientific uncertainties, the degree of restoration likely to be attainable, and the need for comprehensive planning.

Application of Lightweighting Technology to Military Vehicles, Vessels, and Aircraft

Wed, 28 Mar 2012 17:00:01 EST

Lightweighting is a concept well known to structural designers and engineers in all applications areas, from laptops to bicycles to automobiles to buildings and airplanes. Reducing the weight of structures can provide many advantages, including increased energy efficiency, better design, improved usability, and better coupling with new, multifunctional features. While lightweighting is a challenge in commercial structures, the special demands of military vehicles for survivability, maneuverability and transportability significantly stress the already complex process.

Application of Lightweighting Technology to Military Vehicles, Vessels, and Aircraft assesses the current state of lightweighting implementation in land, sea, and air vehicles and recommends ways to improve the use of lightweight materials and solutions. This book considers both lightweight materials and lightweight design; the availability of lightweight materials from domestic manufacturers; and the performance of lightweight materials and their manufacturing technologies. It also considers the "trade space"--that is, the effect that use of lightweight materials or technologies can have on the performance and function of all vehicle systems and components. This book also discusses manufacturing capabilities and affordable manufacturing technology to facilitate lightweighting.

Application of Lightweighting Technology to Military Vehicles, Vessels, and Aircraft will be of interest to the military, manufacturers and designers of military equipment, and decision makers.

Improving Adult Literacy Instruction: Options for Practice and Research

Tue, 27 Mar 2012 17:00:02 EST

A high level of literacy in both print and digital media is required for negotiating most aspects of 21st-century life, including supporting a family, education, health, civic participation, and competitiveness in the global economy. Yet, more than 90 million U.S. adults lack adequate literacy. Furthermore, only 38 percent of U.S. 12th graders are at or above proficient in reading.

Improving Adult Literacy Instruction synthesizes the research on literacy and learning to improve literacy instruction in the United States and to recommend a more systemic approach to research, practice, and policy. The book focuses on individuals ages 16 and older who are not in K-12 education. It identifies factors that affect literacy development in adolescence and adulthood in general, and examines their implications for strengthening literacy instruction for this population. It also discusses technologies for learning that can assist with multiple aspects of teaching, assessment,and accommodations for learning.

There is inadequate knowledge about effective instructional practices and a need for better assessment and ongoing monitoring of adult students' proficiencies, weaknesses, instructional environments, and progress, which might guide instructional planning. Improving Adult Literacy Instruction recommends a program of research and innovation to validate, identify the boundaries of, and extend current knowledge to improve instruction for adults and adolescents outside school. The book is a valuable resource for curriculum developers, federal agencies such as the Department of Education, administrators, educators, and funding agencies.

New Research Opportunities in the Earth Sciences

Tue, 27 Mar 2012 17:00:02 EST

The 2001 National Research Council (NRC) report Basic Research Opportunities in Earth Science (BROES) described how basic research in the Earth sciences serves five national imperatives: (1) discovery, use, and conservation of natural resources; (2) characterization and mitigation of natural hazards; (3) geotechnical support of commercial and infrastructure development; (4) stewardship of the environment; and (5) terrestrial surveillance for global security and national defense. This perspective is even more pressing today, and will persist into the future, with ever-growing emphasis. Today's world-with headlines dominated by issues involving fossil fuel and water resources, earthquake and tsunami disasters claiming hundreds of thousands of lives and causing hundreds of billions of dollars in damages, profound environmental changes associated with the evolving climate system, and nuclear weapons proliferation and testing-has many urgent societal issues that need to be informed by sound understanding of the Earth sciences. A national strategy to sustain basic research and training of expertise across the full spectrum of the Earth sciences is motivated by these national imperatives.

New Research Opportunities in the Earth Sciences identifies new and emerging research opportunities in the Earth sciences over the next decade, including surface and deep Earth processes and interdisciplinary research with fields such as ocean and atmospheric sciences, biology, engineering, computer science, and social and behavioral sciences. The report also identifies key instrumentation and facilities needed to support these new and emerging research opportunities. The report describes opportunities for increased cooperation in these new and emerging areas between EAR and other government agency programs, industry, and international programs, and suggests new ways that EAR can help train the next generation of Earth scientists, support young investigators, and increase the participation of underrepresented groups in the field.

Adverse Effects of Vaccines: Evidence and Causality

Tue, 27 Mar 2012 17:00:02 EST

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children.

Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma.

Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Nutrition and Healthy Aging in the Community: Workshop Summary

Mon, 26 Mar 2012 17:00:01 EST

The U.S. population of older adults is predicted to grow rapidly as "baby boomers" (those born between 1946 and 1964) begin to reach 65 years of age. Simultaneously, advancements in medical care and improved awareness of healthy lifestyles have led to longer life expectancies. The Census Bureau projects that the population of Americans 65 years of age and older will rise from approximately 40 million in 2010 to 55 million in 2020, a 36 percent increase. Furthermore, older adults are choosing to live independently in the community setting rather than residing in an institutional environment. Furthermore, the types of services needed by this population are shifting due to changes in their health issues. Older adults have historically been viewed as underweight and frail; however, over the past decade there has been an increase in the number of obese older persons. Obesity in older adults is not only associated with medical comorbidities such as diabetes; it is also a major risk factor for functional decline and homebound status. The baby boomers have a greater prevalence of obesity than any of their historic counterparts, and projections forecast an aging population with even greater chronic disease burden and disability.

In light of the increasing numbers of older adults choosing to live independently rather than in nursing homes, and the important role nutrition can play in healthy aging, the Institute of Medicine (IOM) convened a public workshop to illuminate issues related to community-based delivery of nutrition services for older adults and to identify nutrition interventions and model programs.

Nutrition and Healthy Aging in the Community summarizes the presentations and discussions prepared from the workshop transcript and slides. This report examines nutrition-related issues of concern experienced by older adults in the community including nutrition screening, food insecurity, sarcopenic obesity, dietary patterns for older adults, and economic issues. This report explores transitional care as individuals move from acute, subacute, or chronic care settings to the community, and provides models of transitional care in the community. This report also provides examples of successful intervention models in the community setting, and covers the discussion of research gaps in knowledge about nutrition interventions and services for older adults in the community.

Small Populations, Large Effects: Improving the Measurement of the Group Quarters Population in the American Community Survey

Fri, 23 Mar 2012 17:00:01 EST

In the early 1990s, the Census Bureau proposed a program of continuous measurement as a possible alternative to the gathering of detailed social, economic, and housing data from a sample of the U.S. population as part of the decennial census. The American Community Survey (ACS) became a reality in 2005, and has included group quarters (GQ)-such places as correctional facilities for adults, student housing, nursing facilities, inpatient hospice facilities, and military barracks-since 2006, primarily to more closely replicate the design and data products of the census long-form sample.

The decision to include group quarters in the ACS enables the Census Bureau to provide a comprehensive benchmark of the total U.S. population (not just those living in households). However, the fact that the ACS must rely on a sample of what is a small and very diverse population, combined with limited funding available for survey operations, makes the ACS GQ sampling, data collection, weighting, and estimation procedures more complex and the estimates more susceptible to problems stemming from these limitations. The concerns are magnified in small areas, particularly in terms of detrimental effects on the total population estimates produced for small areas.

Small Populations, Large Effects provides an in-depth review of the statistical methodology for measuring the GQ population in the ACS. This report addresses difficulties associated with measuring the GQ population and the rationale for including GQs in the ACS. Considering user needs for ACS data and of operational feasibility and compatibility with the treatment of the household population in the ACS, the report recommends alternatives to the survey design and other methodological features that can make the ACS more useful for users of small-area data.

Genome-Based Diagnostics: Clarifying Pathways to Clinical Use: Workshop Report

Fri, 23 Mar 2012 17:00:01 EST

The sequencing of the human genome and the identification of associations between specific genetic variants and diseases have led to an explosion of genomic-based diagnostic tests. These tests have the potential to direct therapeutic interventions, predict risk or onset of disease, or detect residual disease. As research progresses and an increasing number of associations are found, further tests will be developed that can aid in providing personalized treatment options for patients. However, the adoption of genomic diagnostic tests by health care providers has been limited due to a lack of evidence regarding the clinical utility of many tests. Health funders and practitioners lack the data necessary to distinguish which tests can improve practice or the clinical settings in which tests will provide the greatest value. The Roundtable on Translating Genomic-Based Research for Health held a workshop in November 2010 to determine what evidence is needed and how it is viewed by different stakeholders in order to develop genomic diagnostic tests of clinical value.

Genome-Based Diagnostics summarizes the presentations and discussions that took place throughout the workshop. Two presentations, in particular, sparked extensive discussion. One presentation proposed that all genomic diagnostic tests be reviewed and approved by the Food and Drug Administration. The other observed that venture capitalists are no longer investing substantially in the development of genomic diagnostic tests because of a lack of clarity surrounding regulatory and reimbursement pathways. Both presentations suggested the need for major changes in the systems used to develop, regulate, and reimburse genomic diagnostic tests. The report also presents the perspectives of different stakeholders in the development of genomic diagnostic tests. Each stakeholder group has a different set of needs and issues of importance, yet commonalities among them are apparent, such as the need to put patients and health outcomes at the center of discussion and action.

Evolution of Translational Omics: Lessons Learned and the Path Forward

Fri, 23 Mar 2012 17:00:01 EST

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Alzheimer's Diagnostic Guideline Validation: Exploration of Next Steps: Workshop Summary

Thu, 22 Mar 2012 17:00:02 EST

Scientific advances during the last decade now indicate that Alzheimer's disease is a continuous, progressive cognitive disease, most likely beginning many years before dementia is apparent. To discuss the next steps in validating new diagnostic guidelines for Alzheimer's disease, the IOM Forum on Neuroscience and Nervous System Disorders hosted a public workshop session at the Alzheimer's Association International Conference.

Crisis Standards of Care: A Systems Framework for Catastrophic Disaster Response

Wed, 21 Mar 2012 17:00:01 EST

Breast Cancer and the Environment: A Life Course Approach

Wed, 21 Mar 2012 17:00:01 EST

Breast cancer remains the most common invasive cancer among women. The primary patients of breast cancer are adult women who are approaching or have reached menopause; 90 percent of new cases in U.S. women in 2009 were diagnosed at age 45 or older. Growing knowledge of the complexity of breast cancer stimulated a transition in breast cancer research toward elucidating how external factors may influence the etiology of breast cancer.

Breast Cancer and the Environment reviews the current evidence on a selection of environmental risk factors for breast cancer, considers gene-environment interactions in breast cancer, and explores evidence-based actions that might reduce the risk of breast cancer. The book also recommends further integrative research into the elements of the biology of breast development and carcinogenesis, including the influence of exposure to a variety of environmental factors during potential windows of susceptibility during the full life course, potential interventions to reduce risk, and better tools for assessing the carcinogenicity of environmental factors. For a limited set of risk factors, evidence suggests that action can be taken in ways that may reduce risk for breast cancer for many women: avoiding unnecessary medical radiation throughout life, avoiding the use of some forms of postmenopausal hormone therapy, avoiding smoking, limiting alcohol consumption, increasing physical activity, and minimizing weight gain.

Breast Cancer and the Environment sets a direction and a focus for future research efforts. The book will be of special interest to medical researchers, patient advocacy groups, and public health professionals.

Technical Evaluation of the NASA Model for Cancer Risk to Astronauts Due to Space Radiation

Mon, 19 Mar 2012 17:00:01 EST

NASA's current missions to the International Space Station (ISS) and potential future exploration missions involving extended stays by astronauts on the lunar surface, as well as the possibility of near- Earth object (NEO) or Mars missions, present challenges in protecting astronauts from radiation risks. These risks arise from a number of sources, including solar particle events (SPEs), galactic cosmic rays (GCRs), secondary radiation from surface impacts, and even the nuclear isotope power sources transported with the astronauts. The serious early and late radiation health effects potentially posed by these exposures are equally varied, ranging from early signs of radiation sickness to cancer induction. Other possible effects include central nervous system damage, cataracts, cardiovascular damage, heritable effects, impaired wound healing, and infertility.

Recent research, much of which has been sponsored by NASA, has focused on understanding and quantifying the radiation health risks posed by space radiation environments. Although many aspects of the space radiation environments are now relatively well characterized, important uncertainties still exist regarding biological effects and thus regarding the level and types of risks faced by astronauts.

This report presents an evaluation of NASA's proposed space radiation cancer risk assessment model, which is described in the 2011 NASA report, Space Radiation Cancer Risk Projections and Uncertainties--2010. The evaluation in Technical Evaluation of the NASA Model for Cancer Risk to Astronauts Due to Space Radiation considers the model components, input data (for the radiation types, estimated doses, and epidemiology), and the associated uncertainties. This report also identifies gaps in NASA's current research strategy for reducing the uncertainties in cancer induction risks.

Scientific Standards for Studies on Modified Risk Tobacco Products

Mon, 19 Mar 2012 17:00:01 EST

Smoking-related diseases kill more Americans than alcohol, illegal drugs, murder and suicide combined. The passage of the Family Smoking Prevention and Tobacco Control Act of 2009 gave the FDA authority to regulate "modified risk tobacco products" (MRTPs), tobacco products that are either designed or advertised to reduce harm or the risk of tobacco-related disease. MRTPs must submit to the FDA scientific evidence to demonstrate the product has the potential to reduce tobacco related harms as compared to conventional tobacco products. The IOM identifies minimum standards for scientific studies that an applicant would need to complete to obtain an order to market the product from the FDA.

Recapturing NASA's Aeronautics Flight Research Capabilities

Fri, 16 Mar 2012 17:00:01 EST

In the five decades since NASA was created, the agency has sustained its legacy from the National Advisory Committee on Aeronautics (NACA) in playing a major role in U.S. aeronautics research and has contributed substantially to United States preeminence in civil and military aviation. This preeminence has contributed significantly to the overall economy and balance of trade of the United States through the sales of aircraft throughout the world. NASA's contributions have included advanced flight control systems, de-icing devices, thrust-vectoring systems, wing fuselage drag reduction configurations, aircraft noise reduction, advanced transonic airfoil and winglet designs, and flight systems. Each of these contributions was successfully demonstrated through NASA flight research programs. Equally important, the aircraft industry would not have adopted these and similar advances without NASA flight demonstration on full-scale aircraft flying in an environment identical to that which the aircraft are to operate-in other words, flight research.

Flight research is a tool, not a conclusion. It often informs simulation and modeling and wind tunnel testing. Aeronautics research does not follow a linear path from simulation to wind tunnels to flying an aircraft. The loss of flight research capabilities at NASA has therefore hindered the agency's ability to make progress throughout its aeronautics program by removing a primary tool for research.

Recapturing NASA's Aeronautics Flight Research Capabilities discusses the motivation for NASA to pursue flight research, addressing the aspects of the committee's task such as identifying the challenges where research program success can be achieved most effectively through flight research. The report contains three case studies chosen to illustrate the state of NASA ARMD. These include the ERA program and the Fundamental Research Program's hypersonics and supersonics projects. Following these case studies, the report describes issues with the NASA ARMD organization and management and offers solutions. In addition, the chapter discusses current impediments to progress, including demonstrating relevancy to stakeholders, leadership, and the lack of focus relative to available resources.

Recapturing NASA's Aeronautics Flight Research Capabilities concludes that the type and sophistication of flight research currently being conducted by NASA today is relatively low and that the agency's overall progress in aeronautics is severely constrained by its inability to actually advance its research projects to the flight research stage, a step that is vital to bridging the confidence gap. NASA has spent much effort protecting existing research projects conducted at low levels, but it has not been able to pursue most of these projects to the point where they actually produce anything useful. Without the ability to actually take flight, NASA's aeronautics research cannot progress, cannot make new discoveries, and cannot contribute to U.S. aerospace preeminence.

Monitoring HIV Care in the United States: Indicators and Data Systems

Fri, 16 Mar 2012 17:00:01 EST

The number of people living with HIV/AIDS (PLWHA) in the United States is growing each year largely due both to advances in treatment that allow HIV-infected individuals to live longer and healthier lives and due to a steady number of new HIV infections each year. The U.S. Centers for Disease Control and Prevention (CDC) estimates that there were 1.2 million people living with HIV infection in the United States at the end of 2008, the most recent year for which national prevalence data are available. Each year, approximately 16,000 individuals die from AIDS despite overall improvements in survival, and 50,000 individuals become newly infected with HIV. In 2011, the CDC estimated that about three in four people living with diagnosed HIV infection are linked to care within 3 to 4 months of diagnosis and that only half are retained in ongoing care.

In the context of the continuing challenges posed by HIV, the White House Office of National AIDS Policy (ONAP) released a National HIV/AIDS Strategy (NHAS) for the United States in July 2010. The primary goals of the NHAS are to: reduce HIV incidence; increase access to care and optimize health outcomes; and reduce HIV-related health disparities.

Monitoring HIV Care in the United States addresses existing gaps in the collection, analysis, and integration of data on the care and treatment experiences of PLWHA. This report identifies critical data and indicators related to continuous HIV care and access to supportive services, assesses the impact of the NHAS and the ACA on improvements in HIV care, and identifies public and private data systems that capture the data needed to estimate these indicators. In addition, this report addresses a series of specific questions related to the collection, analysis, and dissemination of such data.

Monitoring HIV Care in the United States is the first of two reports to be prepared by this study. In a forthcoming report, also requested by ONAP, the committee will address the broad question of how to obtain national estimates that characterize the health care of people living with HIV in the United States. The second report will include discussion of challenges and best practices from previous large scale and nationally representative studies of PLWHA as well as other populations.

Health IT and Patient Safety: Building Safer Systems for Better Care

Thu, 15 Mar 2012 17:00:01 EST

IOM's 1999 landmark study To Err is Human estimated that between 44,000 and 98,000 lives are lost every year due to medical errors. This call to action has led to a number of efforts to reduce errors and provide safe and effective health care. Information technology (IT) has been identified as a way to enhance the safety and effectiveness of care. In an effort to catalyze its implementation, the U.S. government has invested billions of dollars toward the development and meaningful use of effective health IT.

Designed and properly applied, health IT can be a positive transformative force for delivering safe health care, particularly with computerized prescribing and medication safety. However, if it is designed and applied inappropriately, health IT can add an additional layer of complexity to the already complex delivery of health care. Poorly designed IT can introduce risks that may lead to unsafe conditions, serious injury, or even death. Poor human-computer interactions could result in wrong dosing decisions and wrong diagnoses. Safe implementation of health IT is a complex, dynamic process that requires a shared responsibility between vendors and health care organizations. Health IT and Patient Safety makes recommendations for developing a framework for patient safety and health IT. This book focuses on finding ways to mitigate the risks of health IT-assisted care and identifies areas of concern so that the nation is in a better position to realize the potential benefits of health IT.

Health IT and Patient Safety is both comprehensive and specific in terms of recommended options and opportunities for public and private interventions that may improve the safety of care that incorporates the use of health IT. This book will be of interest to the health IT industry, the federal government, healthcare providers and other users of health IT, and patient advocacy groups.

WARNING: bad characters: Letter Report: The Blue Grass Chemical Agent Destruction Pilot Plant™s Water Recovery System

Wed, 07 Mar 2012 17:00:01 EST

A new facility is under construction to ensure the safe destruction of the chemical weapons stockpile currently in storage at the Blue Grass Army Depot near Richmond, Kentucky. A committee was assembled to review the Water Recovery System at the Blue Grass Chemical Agent Destruction Pilot Plant (BGCAPP) facility and has produced a letter report based on their findings.

The Blue Grass Chemical Agent Destruction Pilot Plant's Water Recovery System discusses the findings of the Committee to Review the Water Recovery System. This report specifically reviews the design and materials of construction of the water recovery system (WRS) that will be used to recycle combined effluents from the supercritical water oxidation (SCWO) system and from the cooling tower and steam blowdown for reuse in the facility.

This report reflects the reservations and recommendations of committee experts, which will be of great use to water treatment and recovery systems experts, particularly those seeking to reuse effluents in their facility.

Interim Report-Status of the Study "An Assessment of the Prospects for Inertial Fusion Energy"

Wed, 07 Mar 2012 17:00:01 EST

The scientific and technological progress in inertial confinement fusion has been substantial during the past decade. However, many of the technologies needed for an integrated inertial fusion energy system are still at an early stage of technological maturity. For all approaches to inertial fusion energy there remain critical scientific and engineering challenges.

In this interim report of the study An Assessment of the Prospects for Inertial Fusion Energy, the Committee on the Prospects for Inertial Confinement Fusion Energy Systems outlines their preliminary conclusions and recommendations of the feasibility of inertial fusion energy. The committee also describes its anticipated next steps as it prepares its final report.

Review of the EPA's Economic Analysis of Final Water Quality Standards for Lakes and Flowing Waters in Florida

Tue, 06 Mar 2012 17:00:01 EST

The Environmental Protection Agency's estimate of the costs associated with implementing numeric nutrient criteria in Florida's waterways was significantly lower than many stakeholders expected. This discrepancy was due, in part, to the fact that the Environmental Protection Agency's analysis considered only the incremental cost of reducing nutrients in waters it considered "newly impaired" as a result of the new criteria-not the total cost of improving water quality in Florida. The incremental approach is appropriate for this type of assessment, but the Environmental Protection Agency's cost analysis would have been more accurate if it better described the differences between the new numeric criteria rule and the narrative rule it would replace, and how the differences affect the costs of implementing nutrient reductions over time, instead of at a fixed time point. Such an analysis would have more accurately described which pollutant sources, for example municipal wastewater treatment plants or agricultural operations, would bear the costs over time under the different rules and would have better illuminated the uncertainties in making such cost estimates.

Biosecurity Challenges of the Global Expansion of High Containment Biological Laboratories

Tue, 06 Mar 2012 17:00:01 EST

During July 10-13, 2011, 68 participants from 32 countries gathered in Istanbul, Turkey for a workshop organized by the United States National Research Council on Anticipating Biosecurity Challenges of the Global Expansion of High-containment Biological Laboratories. The United States Department of State's Biosecurity Engagement Program sponsored the workshop, which was held in partnership with the Turkish Academy of Sciences. The international workshop examined biosafety and biosecurity issues related to the design, construction, maintenance, and operation of high-containment biological laboratories- equivalent to United States Centers for Disease Control and Prevention biological safety level 3 or 4 labs. Although these laboratories are needed to characterize highly dangerous human and animal pathogens, assist in disease surveillance, and produce vaccines, they are complex systems with inherent risks.

Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories summarizes the workshop discussion, which included the following topics:

Technological options to meet diagnostic, research, and other goals;
Laboratory construction and commissioning;
Operational maintenance to provide sustainable capabilities, safety, and security; and
Measures for encouraging a culture of responsible conduct.

Workshop attendees described the history and current challenges they face in their individual laboratories. Speakers recounted steps they were taking to improve safety and security, from running training programs to implementing a variety of personnel reliability measures. Many also spoke about physical security, access controls, and monitoring pathogen inventories. Workshop participants also identified tensions in the field and suggested possible areas for action.

Review of Studies of Possible Toxic Effects from Past Environmental Contamination at Fork Detrick: A Letter Report

Mon, 05 Mar 2012 17:00:01 EST

Fort Detrick's Area B has been used for disposal of chemical, biological, and radiological material, storage of explosives, and research activities. The groundwater of Area B was contaminated by perchloroethylene (PCE) and trichloroethylene (TCE), which leaked from storage drums buried in Area B. Members of the public who live near Fort Detrick in Frederick County, Maryland, are concerned that the contaminated groundwater might have affected their health. This report reviews two investigations of potential health hazards: a 2009 public health assessment conducted by the Agency for Toxic Substances and Disease Registry and a cancer investigation in Frederick County by the Maryland Department of Health and Mental Hygiene and the Frederick County Health Department.

Research Frontiers in Bioinspired Energy: Molecular-Level Learning from Natural Systems: A Workshop

Mon, 05 Mar 2012 17:00:01 EST

In May 2007, the National Academies Chemical Sciences Roundtable held a public workshop on the topic of Bioinspired Chemistry for Energy, where government, academic, and industry representatives discussed promising research developments in solar-generated fuels, hydrogen-processing enzymes, artificial photosynthetic systems, and biological-based fuel cells. Workshop participants identified the need for a follow-up activity that would explore bioinspired energy processes in more depth and involve a wider array of disciplines as speakers and participants. Particularly, workshop participants stressed the importance of holding a workshop that would include more researchers from the biological sciences and engineering, as well as those involved in technological advances that enable progress in understanding these systems.

Building upon the 2007 workshop, the National Academies Board on Chemical Sciences and Technology convened the Committee on Research Frontiers in Bioinspired Energy to organize a second workshop in 2011 which, according to the statement of task, would explore the molecular-level frontiers of energy processes in nature through an interactive, multidisciplinary, and public format. Specifically, the committee was charged to feature invited presentations and include discussion of key biological energy capture, storage, and transformation processes; gaps in knowledge and barriers to transitioning the current state of knowledge into applications; and underdeveloped research opportunities that might exist beyond disciplinary boundaries.

Research Frontiers in Bioinspired Energy is an account of what occurred at the 2011 workshop, and does not attempt to present any consensus findings or recommendations of the workshop participants. It summarizes the views expressed by workshop participants, and while the committee is responsible for the overall quality and accuracy of the report as a record of what transpired at the workshop, the views contained in the report are not necessarily those of the committee.

Macondo Well-Deepwater Horizon Blowout: Lessons for Offshore Drilling Safety

Fri, 02 Mar 2012 17:00:01 EST

The blowout of the Macondo well on April 20, 2010, led to enormous consequences for the individuals involved in the drilling operations, and for their families. Eleven workers on the Deepwater Horizon drilling rig lost their lives and 16 others were seriously injured. There were also enormous consequences for the companies involved in the drilling operations, to the Gulf of Mexico environment, and to the economy of the region and beyond. The flow continued for nearly 3 months before the well could be completely killed, during which time, nearly 5 million barrels of oil spilled into the gulf.

Macondo Well-Deepwater Horizon Blowout examines the causes of the blowout and provides a series of recommendations, for both the oil and gas industry and government regulators, intended to reduce the likelihood and impact of any future losses of well control during offshore drilling. According to this report, companies involved in offshore drilling should take a "system safety" approach to anticipating and managing possible dangers at every level of operation -- from ensuring the integrity of wells to designing blowout preventers that function under all foreseeable conditions-- in order to reduce the risk of another accident as catastrophic as the Deepwater Horizon explosion and oil spill. In addition, an enhanced regulatory approach should combine strong industry safety goals with mandatory oversight at critical points during drilling operations.

Macondo Well-Deepwater Horizon Blowout discusses ultimate responsibility and accountability for well integrity and safety of offshore equipment, formal system safety education and training of personnel engaged in offshore drilling, and guidelines that should be established so that well designs incorporate protection against the various credible risks associated with the drilling and abandonment process. This book will be of interest to professionals in the oil and gas industry, government decision makers, environmental advocacy groups, and others who seek an understanding of the processes involved in order to ensure safety in undertakings of this nature.

Twenty-Third Symposium on Naval Hydrodynamics

Thu, 01 Mar 2012 17:00:01 EST

"Vive la Revolution!" was the theme of the Twenty-Third Symposium on Naval Hydrodynamics held in Val de Reuil, France, from September 17-22, 2000 as more than 140 experts in ship design, construction, and operation came together to exchange naval research developments. The forum encouraged both formal and informal discussion of presented papers, and the occasion provides an opportunity for direct communication between international peers.

This book includes sixty-three papers presented at the symposium which was organized jointly by the Office of Naval Research, the National Research Council (Naval Studies Board), and the Bassin d'Essais des Carènes. This book includes the ten topical areas discussed at the symposium: wave-induced motions and loads, hydrodynamics in ship design, propulsor hydrodynamics and hydroacoustics, CFD validation, viscous ship hydrodynamics, cavitation and bubbly flow, wave hydrodynamics, wake dynamics, shallow water hydrodynamics, and fluid dynamics in the naval context.

Safe and Effective Medicines for Children: Pediatric Studies Conducted Under the Best Pharmaceuticals for Children and the Pediatric Research Equity Acts

Wed, 29 Feb 2012 17:00:01 EST

The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.

A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas

Wed, 29 Feb 2012 17:00:01 EST

Science, engineering, and technology permeate nearly every facet of modern life and hold the key to solving many of humanity's most pressing current and future challenges. The United States' position in the global economy is declining, in part because U.S. workers lack fundamental knowledge in these fields. To address the critical issues of U.S. competitiveness and to better prepare the workforce, A Framework for K-12 Science Education proposes a new approach to K-12 science education that will capture students' interest and provide them with the necessary foundational knowledge in the field.

A Framework for K-12 Science Education outlines a broad set of expectations for students in science and engineering in grades K-12. These expectations will inform the development of new standards for K-12 science education and, subsequently, revisions to curriculum, instruction, assessment, and professional development for educators. This book identifies three dimensions that convey the core ideas and practices around which science and engineering education in these grades should be built. These three dimensions are: crosscutting concepts that unify the study of science through their common application across science and engineering; scientific and engineering practices; and disciplinary core ideas in the physical sciences, life sciences, and earth and space sciences and for engineering, technology, and the applications of science. The overarching goal is for all high school graduates to have sufficient knowledge of science and engineering to engage in public discussions on science-related issues, be careful consumers of scientific and technical information, and enter the careers of their choice.

A Framework for K-12 Science Education is the first step in a process that can inform state-level decisions and achieve a research-grounded basis for improving science instruction and learning across the country. The book will guide standards developers, teachers, curriculum designers, assessment developers, state and district science administrators, and educators who teach science in informal environments.

Progress, Challenges, and Opportunities for Converting U.S. and Russian Research Reactors: A Workshop

Tue, 28 Feb 2012 17:00:01 EST

Highly enriched uranium (HEU) is used for two major civilian purposes: as fuel for research reactors and as targets for medical isotope production. This material can be dangerous in the wrong hands. Stolen or diverted HEU can be used-in conjunction with some knowledge of physics-to build nuclear explosive devices. Thus, the continued civilian use of HEU is of concern particularly because this material may not be uniformly well-protected. To address these concerns, the National Research Council (NRC) of the U.S. National Academies and the Russian Academy of Sciences (RAS) held a joint symposium on June 8-10, 2011.

Progress, Challenges, and Opportunities for Converting U.S. and Russian Research Reactors summarizes the proceedings of this joint symposium. This report addresses: (1) recent progress on conversion of research reactors, with a focus on U.S.- and R.F.-origin reactors; (2) lessons learned for overcoming conversion challenges, increasing the effectiveness of research reactor use, and enabling new reactor missions; (3) future research reactor conversion plans, challenges, and opportunities; and (4) actions that could be taken by U.S. and Russian organizations to promote conversion. The agenda for the symposium is provided in Appendix A, biographical sketches of the committee members are provided in Appendix B, and the report concludes with the statement of task in Appendix C.

Review of Disability and Rehabilitation Research: NIDRR Grantmaking Processes and Products

Mon, 27 Feb 2012 17:00:01 EST

The National Institute on Disability and Rehabilitation Research (NIDRR) is the principal federal agency supporting applied research, training, and development to improve the lives of individuals with disabilities. NIDRR's mission is to generate new knowledge and promote its effective use in improving the ability of persons with disabilities to perform activities of their choice in the community, as well as to expand society's capacity to provide full opportunities and accommodations for its citizens with disabilities.

NIDRR prides itself on being proactive in establishing program performance measures and developing accountability data systems to track the progress of its grantees. An electronic annual reporting system is used to collect data from grantees on many aspects of grant operation and outputs. Various formative and summative evaluation approaches have been used to assess the quality of the performance and results of the agency's research portfolio and its grantees. Prompted by the need to provide more data on its program results, in 2009 NIDRR requested that the National Research Council (NRC) conduct an external evaluation of some of the agency's key processes and assess the quality of outputs produced by NIDRR grantees (National Institute on Disability and Rehabilitation Research, 2009a). Review of Disability and Rehabilitation Research presents the results of that evaluation.

Measuring Progress in Obesity Prevention: Workshop Report

Thu, 23 Feb 2012 17:00:01 EST

Nearly 69 percent of U.S. adults and 32 percent of children are either overweight or obese, creating an annual medical cost burden that may reach $147 billion. Researchers and policy makers are eager to identify improved measures of environmental and policy factors that contribute to obesity prevention. The IOM formed the Committee on Accelerating Progress in Obesity Prevention to review the IOM's past obesity-related recommendations, identify a set of recommendations for future action, and recommend indicators of progress in implementing these actions. The committee held a workshop in March 2011 about how to improve measurement of progress in obesity prevention.

Report of a Workshop on Science, Technology, Engineering, and Mathematics (STEM) Workforce Needs for the U.S. Department of Defense and the U.S. Defense Industrial Base

Wed, 22 Feb 2012 17:00:02 EST

Report of a Workshop on Science, Technology, Engineering, and Mathematics (STEM) Workforce Needs for the U.S. Department of Defense and the U.S. Defense Industrial Base is the summary of a workshop held August 11, 2011 as part of an 18-month study of the issue. This book assesses the STEM capabilities that the Department of Defense (DOD) needs in order to meet its goals, objectives, and priorities; to assess whether the current DOD workforce and strategy will meet those needs; and to identify and evaluate options and recommend strategies that the department could use to help meet its future STEM needs.

Managing for High-Quality Science and Engineering at the NNSA National Security Laboratories

Tue, 21 Feb 2012 17:00:01 EST

The three National Security Laboratories--Los Alamos National Laboratory (LANL), Sandia National Laboratories (SNL), and Lawrence Livermore National Laboratory (LLNL)--are managed by private-sector entities under contract to the National Nuclear Security Administration (NNSA). The FY2010 Defense Authorization Act mandated that NNSA task the National Research Council (NRC) to study the quality and management of Science and Engineering (S&E) at these Laboratories.

This study (addressing a total of 5 tasks) is being conducted in two phases. This report covers the first phase, which addresses the relationship between the quality of the science and engineering at the Laboratory and the contract for managing and operating the Laboratory (task 4), and also addresses the management of work conducted by the Laboratory for entities other than the Department of Energy (task 5). The study's second phase will evaluate the actual quality of S&E in key subject areas.

Managing for High-Quality Science and Engineering at the NNSA National Security Laboratories presents assessments of the evolution of the mission of the NNSA Labs and the management and performance of research in support of the missions, and the relationship between the Laboratory Directed Research and Development (LDRD) program and the ability of the Labs to fulfill their mission. The report examines the framework for managing science and engineering research at the Labs and provides an analysis of the relationships among the several players in the management of the Labs--the NNSA, the site offices, the contractors, and the Lab managers--and the effect of that relationship on the Laboratories' ability to carry out science and engineering research.

Facilitating State Health Exchange Communication Through the Use of Health Literate Practices: Workshop Summary

Tue, 21 Feb 2012 17:00:01 EST

Implementation of the Affordable Care Act (ACA) of 2010 will result in significant changes to the U.S. health care system. Among its many provisions, the ACA will extend access to health care coverage to millions of Americans who have been previously uninsured. Many of the newly eligible health insurance consumers will be individuals of low health literacy, some speakers of English and others more comfortable using languages other than English. Health insurance terms such as "deductible," "co-insurance," and "out-of-pocket limit" are difficult to communicate even to those with moderate-to-high levels of health literacy and so health exchanges will face challenges as they attempt to communicate to the broader community. In addition to having to convey some of these basic, and yet complex, principles of insurance, state exchanges will be attempting to adapt to the many changes to enrollment and eligibility brought about by ACA.

The Institute of Medicine (IOM) convened the Roundtable on Health Literacy that brings together leaders from the federal government, foundations, health plans, associations, and private companies to discuss challenges facing health literacy practice and research and to identify approaches to promote health literacy in both the public and private sectors. The roundtable sponsored a workshop in Washington, DC, on July 19, 2011, that focused on ways in which health literacy can facilitate state health insurance exchange communication with potential enrollees. The roundtable's workshop focused on four topics: (1) lessons learned from existing state insurance exchanges; (2) the impact of state insurance exchanges on consumers; (3) the relevance of health literacy to health insurance exchanges; and (4) current best practices in developing materials and communicating with consumers.

Facilitating State Health Exchange Communication Through the Use of Health Literate Practices summarizes the presentations and discussion that occurred during the workshop. The report provides an overview of health insurance exchanges, presents evidence on the extent to which consumers understand underlying health insurance concepts, and describes the relevancy of health literacy to health insurance reform and how health literacy interventions can facilitate the implementation of health insurance reforms. The report also provides a review of best practices in developing materials and communicating with consumers, and concludes with reflections on the workshop presentations and discussions by members of the roundtable and its chair. Further information is provided in the appendixes, the workshop agenda (Appendix A), workshop speaker biosketches (Appendix B), and testimony provided by the organization America's Health Insurance Plans (AHIP) (Appendix C).

Approaches for Ecosystem Services Valuation for the Gulf of Mexico After the Deepwater Horizon Oil Spill: Interim Report

Tue, 21 Feb 2012 17:00:01 EST

On April 20th 2010, the Deepwater Horizon platform drilling the Macondo well in Mississippi Canyon Block 252 (DWH) exploded, killing 11 workers and injuring another 17. The DWH oil spill resulted in nearly 5 million barrels (approximately 200 million gallons) of crude oil spilling into the Gulf of Mexico (GoM). The full impacts of the spill on the GoM and the people who live and work there are unknown but expected to be considerable, and will be expressed over years to decades. In the short term, up to 80,000 square miles of the U.S. Exclusive Economic Zone (EEZ) were closed to fishing, resulting in loss of food, jobs and recreation.

The DWH oil spill immediately triggered a process under the U.S. Oil Pollution Act of 1990 (OPA) to determine the extent and severity of the "injury" (defined as an observable or measurable adverse change in a natural resource or impairment of a natural resource service) to the public trust, known as the Natural Resources Damage Assessment (NRDA). The assessment, undertaken by the trustees (designated technical experts who act on behalf of the public and who are tasked with assessing the nature and extent of site-related contamination and impacts), requires: (1) quantifying the extent of damage; (2) developing, implementing, and monitoring restoration plans; and (3) seeking compensation for the costs of assessment and restoration from those deemed responsible for the injury.

This interim report provides options for expanding the current effort to include the analysis of ecosystem services to help address the unprecedented scale of this spill in U.S. waters and the challenges it presents to those charged with undertaking the damage assessment.

Challenges and Opportunities in the Hydrologic Sciences

Thu, 16 Feb 2012 17:00:02 EST

New research opportunities to advance hydrologic sciences promise a better understanding of the role of water in the Earth system that could help improve human welfare and the health of the environment. Reaching this understanding will require both exploratory research to better understand how the natural environment functions, and problem-driven research, to meet needs such as flood protection, supply of drinking water, irrigation, and water pollution. Collaboration among hydrologists, engineers, and scientists in other disciplines will be central to meeting the interdisciplinary research challenges outline in this report. New technological capabilities in remote sensing, chemical analysis, computation, and hydrologic modeling will help scientists leverage new research opportunities.

International Science in the National Interest at the U.S. Geological Survey

Wed, 15 Feb 2012 17:00:02 EST

Science at the U.S. Geological Survey is intrinsically global, and from early in its history, the USGS has successfully carried out international projects that serve U.S. national interests and benefit the USGS domestic mission. Opportunities abound for the USGS to strategically pursue international science in the next 5-10 years that bears on growing worldwide problems having direct impact on the United States-climate and ecosystem changes, natural disasters, the spread of invasive species, and diminishing natural resources, to name a few. Taking a more coherent, proactive agency approach to international science-and building support for international projects currently in progress-would help the USGS participate in international science activities more effectively.

The Early Childhood Care and Education Workforce: Challenges and Opportunities: A Workshop Report

Mon, 13 Feb 2012 17:00:02 EST

Early childhood care and education (ECCE) settings offer an opportunity to provide children with a solid beginning in all areas of their development. The quality and efficacy of these settings depend largely on the individuals within the ECCE workforce. Policy makers need a complete picture of ECCE teachers and caregivers in order to tackle the persistent challenges facing this workforce. The IOM and the National Research Council hosted a workshop to describe the ECCE workforce and outline its parameters. Speakers explored issues in defining and describing the workforce, the marketplace of ECCE, the effects of the workforce on children, the contextual factors that shape the workforce, and opportunities for strengthening ECCE as a profession.

Frontiers of Engineering 2011: Reports on Leading-Edge Engineering from the 2011 Symposium

Fri, 10 Feb 2012 17:00:01 EST

The practice of engineering is continually changing. Engineers today must be able not only to thrive in an environment of rapid technological change and globalization, but also to work on interdisciplinary teams. Cutting-edge research is being done at the intersections of engineering disciplines, and successful researchers and practitioners must be aware of developments and challenges in areas that may not be familiar to them.

At the U.S. Frontiers of Engineer Symposium, engineers have the opportunity to learn from their peers about pioneering work being done in many areas of engineering. Frontiers of Engineering 2011: Reports on Leading-Edge Engineering from the 2011 Symposium highlights the papers presented at the event. This book covers four general topics from the 2011 symposium: additive manufacturing, semantic processing, engineering sustainable buildings, and neuro-prosthetics. The papers from these presentations provide an overview of the challenges and opportunities of these fields of inquiry, and communicate the excitement of discovery.

Social and Economic Costs of Violence: Workshop Summary

Thu, 09 Feb 2012 17:00:02 EST

Measuring the social and economic costs of violence can be difficult, and most estimates only consider direct economic effects, such as productivity loss or the use of health care services. Communities and societies feel the effects of violence through loss of social cohesion, financial divestment, and the increased burden on the healthcare and justice systems. Initial estimates show that early violence prevention intervention has economic benefits. The IOM Forum on Global Violence Prevention held a workshop to examine the successes and challenges of calculating direct and indirect costs of violence, as well as the potential cost-effectiveness of intervention.

Communicating Science and Engineering Data in the Information Age

Tue, 07 Feb 2012 17:00:02 EST

The National Center for Science and Engineering Statistics (NCSES) of the National Science Foundation (NSF) communicates its science and engineering (S&E) information to data users in a very fluid environment that is undergoing modernization at a pace at which data producer dissemination practices, protocols, and technologies, on one hand, and user demands and capabilities, on the other, are changing faster than the agency has been able to accommodate. NCSES asked the Committee on National Statistics and the Computer Science and Telecommunications Board of the National Research Council to form a panel to review the NCSES communication and dissemination program that is concerned with the collection and distribution of information on science and engineering and to recommend future directions for the program.

Communicating Science and Engineering Data in the Information Age includes recommendations to improve NCSES's dissemination program and improve data user engagement. This report includes recommendations such as NCSES's transition to a dissemination framework that emphasizes database management rather than data presentation, and that NCSES analyze the results of its initial online consumer survey and refine it over time. The implementation of the report's recommendations should be undertaken within an overall framework that accords priority to the basic quality of the data and the fundamentals of dissemination, then to significant enhancements that are achievable in the short term, while laying the groundwork for other long-term improvements.

Facilitating Collaborations to Develop Combination Investigational Cancer Therapies: Workshop Summary

Tue, 07 Feb 2012 17:00:02 EST

Advances in biomedical research have increased our understanding of the complex nature of disease and the interaction of multiple molecular pathways involved in cancer. Combining investigational products early in their development is thought to be a promising strategy for identifying effective therapies. The IOM's National Cancer Policy Forum held a workshop to discuss challenges and identify potential solutions to improve collaboration and advance the development of combination investigational cancer therapies.

Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary

Tue, 07 Feb 2012 17:00:02 EST

The initial sequencing of the human genome, carried out by an international group of experts, took 13 years and $2.7 billion to complete. In the decade since that achievement, sequencing technology has evolved at such a rapid pace that today a consumer can have his or her entire genome sequenced by a single company in a matter of days for less than $10,000, though the addition of interpretation may extend this timeframe. Given the rapid technological advances, the potential effect on the lives of patients, and the increasing use of genomic information in clinical care, it is important to address how genomics data can be integrated into the clinical setting. Genetic tests are already used to assess the risk of breast and ovarian cancers, to diagnose recessive diseases such as cystic fibrosis, to determine drug dosages based on individual patient metabolism, and to identify therapeutic options for treating lung and breast tumors, melanoma, and leukemia.

With these issues in mind and considering the potential impact that genomics information can have on the prevention, diagnosis, and treatment of disease, the Roundtable on Translating Genomic-Based Research for Health hosted a workshop on July 19, 2011, to highlight and identify the challenges and opportunities in integrating large-scale genomic information into clinical practice.

Integrating Large-Scale Genomic Information into Clinical Practice summarizes the speaker presentations and the discussions that followed them. This report focuses on several key topics, including the analysis, interpretation, and delivery of genomic information plus workforce, ethical, and legal issues.

A Technical Analysis of the Common Carrier/User Interconnections Area

Mon, 06 Feb 2012 17:00:02 EST

A Technical Analysis of the Common Carrier/User Interconnections Area assesses the technical factors affecting the common carrier/user interconnection area of public communications. This book develops technical and background information that might be useful to common carriers, users, and equipment manufacturers in reaching and implementing solutions to immediate problems. This includes a technical evaluation of various contending points fo view regarding the common carrier/user interaction area, the various problems to which these views relate, and the various technical and policy alternatives for responding to these problems in the near future. 
 A Technical Analysis of the Common Carrier/User Interconnections Area addresses questions of the propriety of the telephone company-provided network control signalling requirements and various alternatives to the provision thereof by the telephone company; the necessity and characteristics of telephone company-provided connecting arrangements and various alternatives to the provison thereof by the telephone company; and basic standards and specifications for interconnection and the appropriate method to administer them..

Recommended Dietary Allowances

Mon, 06 Feb 2012 17:00:02 EST

A guide to serve as a goal for good nutrition and as a yardstick by which to measure progress toward that goal has long been needed. The Committee on Food and Nutrition of the National Research Council was established in 1940 to advise on nutrition problems in connection with national defense. One of its first concerns was to work out recommended daily allowances for the various dietary essentials, for people of different ages. Recommended Dietary Allowances develops a table of allowances that represents the best available evidence on the amounts of the various nutritive essentials desirable to include in practical diets. These values represent the combined judgment of nutrition authorities in various parts of the country. This information serves as a guide for planning adequate nutrition for the civilian population of the United States.

Report of the Committee on Ballistic Acoustics

Mon, 06 Feb 2012 17:00:02 EST

At the time of the assassination of President Kennedy the Dallas police recorded sounds from an open microphone; these sounds have been previously analyzed by two research groups at the request of the House Select Committee on Assassinations. Both groups concluded with 95% probability that the recordings contained acoustic impulses which provide evidence for the existence of a shot from the grassy knoll area of Dealey Plaza. On the basis of these results and since shots definitely were fired from the Texas School Book Depository, the House Committee concluded that "scientific acoustical evidence establishes a high probability that two gunmen fired at President John F. Kennedy.

Report of the Committee on Ballistic Acoustics studied these reports and the Dallas Police recordings on which they are based. This book reviews the methodology employed in the evaluations of the recorded acoustic data and of the conclusions about the existence of a shot from the grassy knoll. According to this report, the acoustic analyses do not demonstrate that there was a grassy knoll shot, and in particular there is no acoustic basis for the claim of 95% probability of such a shot. The acoustic impulses attributed to gunshots were recorded about one minute after the President had been shot and the motorcade had been instructed to go to the hospital. Therefore, reliable acoustic data do not support a conclusion that there was a second gunman.

Improving Measures of Science, Technology, and Innovation: Interim Report

Fri, 03 Feb 2012 17:00:02 EST

The National Center for Science and Engineering Statistics (NCSES), at the U.S. National Foundation, is one of 14 major statistical agencies in the federal government, of which at least five collect relevant information on science, technology, and innovation activities in the United States and abroad. The America COMPETES Reauthorization Act of 2010 expanded and codified NCSES's role as a U.S. federal statistical agency. Important aspects of the agency's mandate include collection, acquisition, analysis, and reporting and dissemination of data on research and development trends, on U.S. competitiveness in science, technology, and research and development, and on the condition and progress of U.S. science, technology, engineering, and mathematics (STEM) education.

Improving Measures of Science, Technology and Innovation: Interim Report examines the status of the NCSES's science, technology, and innovation (STI) indicators. This report assesses and provides recommendations regarding the need for revised, refocused, and newly developed indicators designed to better reflect fundamental and rapid changes that are reshaping global science, technology and innovation systems. The book also determines the international scope of STI indicators and the need for developing new indicators that measure developments in innovative activities in the United States and abroad, and Offers foresight on the types of data, metrics and indicators that will be particularly influential in evidentiary policy decision-making for years to come.

In carrying out its charge, the authoring panel undertook a broad and comprehensive review of STI indicators from different countries, including Japan, China, India and several countries in Europe, Latin America and Africa. Improving Measures of Science, Technology, and Innovation makes recommendations for near-term action by NCSES along two dimensions: (1) development of new policy-relevant indicators that are based on NCSES survey data or on data collections at other statistical agencies; and (2) exploration of new data extraction and management tools for generating statistics, using automated methods of harvesting unstructured or scientometric data and data derived from administrative records.

Assessment of a Plan for U.S. Participation in Euclid

Fri, 03 Feb 2012 17:00:02 EST

NASA has proposed to make a hardware contribution to the European Space Agency's (ESA's) Euclid mission in exchange for U.S. membership on the Euclid Science Team and science data access. The Euclid mission will employ a space telescope that will make potentially important contributions to probing dark energy and to the measurement of cosmological parameters. Euclid will image a large fraction of the extragalactic sky at unprecedented resolution and measure spectra for millions of galaxies.

Assessment of a Plan for U.S. Participation in Euclid evaluates whether a small investment in Euclid (around $20 million in hardware) is a viable part of an overall strategy to pursue the science goals set forth in New Worlds, New Horizons in Astronomy and Astrophysics, a decadal plan for ground- and space- based astronomy and astrophysics. The top-ranked large-scale, space-based priority of the New Worlds, New Horizons is the Wide-Field Infrared Survey Telescope (WFIRST). WFIRST has a broad, wide-field, near-infrared capability that will serve a wide variety of science programs of U.S. astronomers, including exoplanet research, near-infrared sky surveys, a guest observer program, and dark energy research. In carrying out this study the authoring committee's intent has been to be clear that this report does not alter New Worlds, New Horizon's plans for the implementation of the survey's priorities.

Assessment of a Plan for U.S. Participation in Euclid concludes that the NASA proposal would represent a valuable first step toward meeting one of the science goals (furthering dark energy research) of WFIRST. While WFIRST dark energy measurements are expected to be superior to Euclid's, U.S. participation in Euclid will have clear scientific, technical, and programmatic benefits to the U.S. community as WFIRST and Euclid go forward. According to this report, the current NASA proposal, to invest modestly in Euclid, is consistent with an expeditious development of WFIRST and the achievement of the broader, and more ambitious, goals outlined in New Worlds, New Horizons. Knowledge gained from the Euclid project could help optimize the science return of the WFIRST mission as well. Such an investment will further the goals of New Worlds, New Horizons, be helpful to the preparations for WFIRST, and enhance WFIRST's chances of success.

Making Things: 21st Century Manufacturing and Design: Summary of a Forum

Fri, 03 Feb 2012 17:00:02 EST

More than two decades ago, a commission of 17 MIT scientists and economists released a report, Made in America, which opened with the memorable phrase, "To live well, a nation must produce well." Is that still true? Or can the United States remain a preeminent nation while other countries increasingly make the products that once were made in America?

These questions were at the center of a forum titled "Making Things: 21st Century Manufacturing and Design" held during the 2011 Annual Meeting of the National Academy of Engineering. In a wide-ranging and provocative conversation, seven leaders of business, government, and academia explored the many facets of manufacturing and design and outlined the many opportunities and responsibilities posed by manufacturing for the engineering profession.

Making Things: 21st Century Manufacturing and Design summarizes the discussions that took place during the 2011 forum. The report concludes with a forum agenda and each attendee's bibliography.

In the Light of Evolution V: Cooperation and Conflict

Fri, 03 Feb 2012 17:00:02 EST

Biodiversity-the genetic variety of life-is an exuberant product of the evolutionary past, a vast human-supportive resource (aesthetic, intellectual, and material) of the present, and a rich legacy to cherish and preserve for the future. Two urgent challenges, and opportunities, for 21st-century science are to gain deeper insights into the evolutionary processes that foster biotic diversity, and to translate that understanding into workable solutions for the regional and global crises that biodiversity currently faces. A grasp of evolutionary principles and processes is important in other societal arenas as well, such as education, medicine, sociology, and other applied fields including agriculture, pharmacology, and biotechnology. The ramifications of evolutionary thought also extend into learned realms traditionally reserved for philosophy and religion.

The central goal of the In the Light of Evolution (ILE) series is to promote the evolutionary sciences through state-of-the-art colloquia--in the series of Arthur M. Sackler colloquia sponsored by the National Academy of Sciences--and their published proceedings. Each installment explores evolutionary perspectives on a particular biological topic that is scientifically intriguing but also has special relevance to contemporary societal issues or challenges. This book is the outgrowth of the Arthur M. Sackler Colloquium "Cooperation and Conflict," which was sponsored by the National Academy of Sciences on January 7-8, 2011, at the Academy's Arnold and Mabel Beckman Center in Irvine, California. It is the fifth in a series of colloquia under the general title "In the Light of Evolution." The current volume explores recent developments in the study of cooperation and conflict, ranging from the level of the gene to societies and symbioses.

Humans can be vicious, but paradoxically we are also among nature's great cooperators. Even our great conflicts-wars-are extremely cooperative endeavors on each side. Some of this cooperation is best understood culturally, but we are also products of evolution, with bodies, brains, and behaviors molded by natural selection. How cooperation evolves has been one of the big questions in evolutionary biology, and how it pays or does not pay is a great intellectual puzzle. The puzzle of cooperation was the dominant theme of research in the early years of Darwin's research, whereas recent work has emphasized its importance and ubiquity. Far from being a rare trait shown by social insects and a few others, cooperation is both widespread taxonomically and essential to life. The depth of research on cooperation and conflict has increased greatly, most notably in the direction of small organisms.

Although most of In the Light of Evolution V: Cooperation and Conflict is about the new topics that are being treated as part of social evolution, such as genes, microbes, and medicine, the old fundamental subjects still matter and remain the object of vigorous research. The first four chapters revisit some of these standard arenas, including social insects, cooperatively breeding birds, mutualisms, and how to model social evolution.

An Assessment of the Deep Underground Science and Engineering Laboratory

Fri, 03 Feb 2012 17:00:02 EST

According to the big bang theory, our Universe began in a state of unimaginably high energy and density, contained in a space of subatomic dimensions. At that time, unlike today, the fundamental forces of nature were presumably unified and the particles present were interacting at energies not attainable by present-day accelerators. Underground laboratories provide the conditions to investigate processes involving rare phenomena in matter and to detect the weak effects of highly elusive particles by replicating similar environments to those once harnessed during the earliest states of the Earth. These laboratories now appear to be the gateway to understanding the physics of the grand unification of the forces of nature.

Built to shield extremely sensitive detectors from the noise of their surroundings and the signals associated with cosmic rays, underground facilities have been established during the last 30 years at a number of sites worldwide. To date, the United States' efforts to develop such facilities have been modest and consist primarily of small underground laboratories. However, the U.S. underground community has pushed for larger underground facilities on the scale of major laboratories in other countries. An Assessment of the Deep Underground Science and Engineering Laboratory (DUSEL) addresses this matter by evaluating the major physics questions and experiments that could be explored with the proposed DUSEL. Measuring the potential impact, this assessment also examines the broader effects of the DUSEL in regards to education and public outreach, and evaluates the need associated with developing U.S. programs similar to science programs in other regions of the world.

A Review of the Proposed Revisions to the Federal Principles and Guidelines Water Resources Planning Document

Fri, 03 Feb 2012 17:00:02 EST

Since it was issued in 1983, the federal document Economic and Environmental Principles and Guidelines for Water and Related Land Resources Implementation Studies (the P&G) has guided water resources project planning for four federal agencies. Since the early 1980s, however, there have been many changes in the national water resources planning landscape. In light of these developments, many groups -- including committees of the National Research Council -- have recommended that the P&G be reviewed and modernized. In 2007 the U.S. Congress directed the Secretary of the Army to revise the P&G. Congress also directed the Secretary to consult with other entities, including the National Academy of Sciences. The Council on Environmental Quality (CEQ) released its "Proposed National Objectives, Principles and Standards for Water and Related Resources Implementation Studies" in December, 2009. The present report from the National Research Council constitutes a review of the 2009 document issued by the CEQ.

An effort to modernize the P&G document so that it reflects contemporary planning methods and principles, and today's societal and economic priorities, is timely. However, as this report explains, the 2009 proposed revisions lack clarity and consistency in several respects. Given that the 2009 document represents only a partial revision to the P&G document, and given several areas of ambiguity and incompleteness in the 2009 proposed revisions, detailed advice on specific planning procedures at this point would be premature. As CEQ proceeds with further revisions to the P&G document, clarification and specification in these areas detailed below will be necessary for the document to be of value to CEQ and the federal agencies that will use the document in decision making.

Predicting Outcomes from Investments in Maintenance and Repair for Federal Facilities

Tue, 31 Jan 2012 17:00:02 EST

The deteriorating condition of federal facilities poses economic, safety, operational, and environmental risks to the federal government, to the achievement of the missions of federal agencies, and to the achievement of public policy goals. Primary factors underlying this deterioration are the age of federal facilities--about half are at least 50 years old--and decades of inadequate investment for their maintenance and repair. These issues are not new and there are no quick fixes. However, the current operating environment provides both the impetus and the opportunity to place investments in federal facilities' maintenance and repair on a new, more sustainable course for the 21st Century. Despite the magnitude of investments, funding for the maintenance and repair of federal facilities has been inadequate for many years, and myriad projects have been deferred.

Predicting Outcomes of Investments in Maintenance and Repair of Federal Facilities identifies processes and practices for transforming the current portfolio of federal facilities into one that is more economically, physically, and environmentally sustainable. This report addresses ways to predict or quantify the outcomes that can be expected from a given level of maintenance and repair investments in federal facilities or facilities' systems, and what strategies, measures, and data should be in place to determine the actual outcomes of facilities maintenance and repair investments.

Establishment of a Solar Energy Research Institute

Mon, 30 Jan 2012 17:00:03 EST

The establishment of the Solar Energy Research Institute (SERI) reflects a public assessment of the importance of solar energy as a nonpolluting, enduring source of energy and Congressional desire for activity in solar energy comparable with that which the nation has supported for the last 25 years in nuclear energy.

Establishment of a Solar Energy Research Institute makes recommendations for the role and direction for research of the SERI. According to this book, SERI will indeed fill an urgent need for a central intellectual and technical resource on all phases of solar energy. SERI should go beyond establishing a program for its own activities in energy research and development to provide a sound by imaginative view of the entire solar-energy field. In conducting this program, in collaboration with industry, government, universities, and other participants in the national scene SERI can make a major contribution to the early, efficient, and economic exploitation of solar energy.

The book further explores the role of SERI in combining technical, economic, sociological, and environmental analyses of changing energy resources and societal demands, including the need for commodities whose manufacture requires much energy. It finds that this broad assessment and analysis is essential not only for efficient utilization of the resources represented by SERI but also for support of the national program in solar energy. The book sets forth three goals for SERI that mutually support and reinforce one another:

1. Improve our technical and analytical tools for solar energy and related fields
2. Provide sound assessments of status and options for policy for solar energy
3. Facilitate in a collaborative, educational, and supportive role the widespread introduction of commercially attractive and environmentally acceptable solar-energy sources.

The recommendations of Establishment of Solar Energy Research Institute are intended to represent a new model for harnessing science, technology, and analysis in the service of the nation.

Information Sharing and Collaboration: Applications to Integrated Biosurveillance: Workshop Summary

Mon, 30 Jan 2012 17:00:03 EST

After the September 11, 2001, terrorist attacks and subsequent anthrax mailings, the U.S. government prioritized a biosurveillance strategy aimed at detecting, monitoring, and characterizing national security health threats in human and animal populations, food, water, agriculture, and the environment. However, gaps and challenges in biosurveillance efforts and integration of biosurveillance activities remain. September 8-9, 2011, the IOM held a workshop to explore the information-sharing and collaboration processes needed for the nation's integrated biosurveillance strategy.

Industrial Methods for the Effective Development and Testing of Defense Systems

Mon, 30 Jan 2012 17:00:03 EST

Over the past decade and a half, the National Research Council, through its Committee on National Statistics, has carried out a number of studies on the application of statistical methods to improve the testing and development of defense systems. These studies were intended to provide advice to the Department of Defense (DOD), which sponsored these studies. The previous studies have been concerned with the role of statistical methods in testing and evaluation, reliability practices, software methods, combining information, and evolutionary acquisition.

Industrial Methods for the Effective Testing and Development of Defense Systems is the latest in a series of studies, and unlike earlier studies, this report identifies current engineering practices that have proved successful in industrial applications for system development and testing. This report explores how developmental and operational testing, modeling and simulation, and related techniques can improve the development and performance of defense systems, particularly techniques that have been shown to be effective in industrial applications and are likely to be useful in defense system development. In addition to the broad issues, the report identifies three specific topics for its focus: finding failure modes earlier, technology maturity, and use of all relevant information for operational assessments.

Improving Metrics for the Department of Defense Cooperative Threat Reduction Program

Mon, 30 Jan 2012 17:00:03 EST

The Cooperative Threat Reduction (CTR) Program was created in 1991 as a set of support activities assisting the Former Soviet Union states in securing and eliminating strategic nuclear weapons and the materials used to create them. The Program evolved as needs and opportunities changed: Efforts to address biological and chemical threats were added, as was a program aimed at preventing cross-border smuggling of weapons of mass destruction. CTR has traveled through uncharted territory since its inception, and both the United States and its partners have taken bold steps resulting in progress unimagined in initial years. Over the years, much of the debate about CTR on Capitol Hill has concerned the effective use of funds, when the partners would take full responsibility for the efforts, and how progress, impact, and effectiveness should be measured.

Directed by Congress, the Secretary of Defense completed a report describing DoD's metrics for the CTR Program (here called the DoD Metrics Report) in September 2010 and, as required in the same law, contracted with the National Academy of Sciences to review the metrics DoD developed and identify possible additional or alternative metrics, if necessary. Improving Metrics for the DoD Cooperative Threat Reduction Program provides that review and advice.

Improving Metrics for the DoD Cooperative Threat Reduction Program identifies shortcomings in the DoD Metrics Report and provides recommendations to enhance DoD's development and use of metrics for the CTR Program. The committee wrote this report with two main audiences in mind: Those who are mostly concerned with the overall assessment and advice, and those readers directly involved in the CTR Program, who need the details of the DoD report assessment and of how to implement the approach that the committee recommends.

Prepositioning Antibiotics for Anthrax

Thu, 26 Jan 2012 17:00:02 EST

If terrorists released Bacillus anthracis over a large city, hundreds of thousands of people could be at risk of the deadly disease anthrax-caused by the B. anthracis spores-unless they had rapid access to antibiotic medical countermeasures (MCM). Although plans for rapidly delivering MCM to a large number of people following an anthrax attack have been greatly enhanced during the last decade, many public health authorities and policy experts fear that the nation's current systems and plans are insufficient to respond to the most challenging scenarios, such as a very large-scale anthrax attack. The U.S. Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response commissioned the Institute of Medicine to examine the potential uses, benefits, and disadvantages of strategies for repositioning antibiotics. This involves storing antibiotics close to or in the possession of the people who would need rapid access to them should an attack occur.

Prepositioning Antibiotics for Anthrax reviews the scientific evidence on the time window in which antibiotics successfully prevent anthrax and the implications for decision making about prepositioning, describes potential prepositioning strategies, and develops a framework to assist state, local, and tribal public health authorities in determining whether prepositioning strategies would be beneficial for their communities. However, based on an analysis of the likely health benefits, health risks, and relative costs of the different prepositioning strategies, the book also develops findings and recommendations to provide jurisdictions with some practical insights as to the circumstances in which different prepositioning strategies may be beneficial. Finally, the book identifies federal- and national-level actions that would facilitate the evaluation and development of prepositioning strategies.

Recognizing that communities across the nation have differing needs and capabilities, the findings presented in this report are intended to assist public health officials in considering the benefits, costs, and trade-offs involved in developing alternative prepositioning strategies appropriate to their particular communities.